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Revision as of 12:44, 27 April 2018

Home>Using helminths>Hookworm timeline>The helminthic therapy bounce

The 'bounce'

The bounce is a brief period of temporary, yet sometimes profound, symptom relief following inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] that is accompanied by a sudden feeling of unusual wellness, and perhaps also by a strong sense of calm, focus, happiness and lightheartedness. The cessation of symptoms can be so profound that it is easy to assume that the worms have “worked” and that all will be well form this point onwards. Unfortunately, the bounce is always temporary and one should not suddenly abandon whatever medications one is taking (see Combining helminthic therapy with drug treatments) or the special diet one is following.

All the therapeutic helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] can produce this effect but the experience varies widely between individuals and may not appear at all in some.

In the case of hookwormsA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin., the bounce typically occurs around the end of the first week following inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation], perhaps as early as day five and even as late as week two. There has been an occasional report of a bounce, or a bounce-like experience, occurring much later, as in one noteworthy case where a significant bounce was experienced at 8 weeks. [1] The bounce may appear for only 3-4 days but can last about a week and, rarely, for two or even three weeks.

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My (NAthe human hookworm, Necator americanus) bounce effects: increased energy/decreased fatigue; able to tolerate lower temperatures without usual adverse reactions; able to tolerate foods with less adverse reactions; reduction in eczema inflammation and clearer complexion (observed by wife!!!); increased sense of emotional well being; increased quality of sleep - had first dream I could remember the details of for longer that I can recall. [2]
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The bounce is here. Started on Day 11 of my first inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] of 5 NAthe human hookworm, Necator americanus. I've slept better than I have since I can remember. My energy is up. My body temperature is up to normal/near normal. But the most surprising thing is the sense of optimism. Not something I've have much of after being sick for most of a decade. [3]
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So I was waiting for the "bounce" and nothing was happening. Then I realized.... I feel good. I feel happy. I'm laughing with people at work. So many years of fake-smiling. I don't feel hyper. I just feel GOOD. [4]

Some users of NAthe human hookworm, Necator americanus continue to experience a bounce following supplementary doses.

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The last time I inoculated (with NAthe human hookworm, Necator americanus), I felt high for much of the first week. I don't know what that was exactly - my inflammation going down so feeling like a normal person was like being high or something else. I felt extremely "spiritual" for lack of a better word, suffused with well-being and connected to the universe (ha, ha.) Too bad it doesn't last. [5]
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I get the bounce too. In fact, it lets me know that I got a good inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation]. I currently inoculate with 1 hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. larvaThe active immature form of an insect, or an animal such as a helminth, which develops from an egg and eventually transforms again into its adult state. every week, so my initial itch is muted enough that it doesn't tell me for sure if the larvaThe active immature form of an insect, or an animal such as a helminth, which develops from an egg and eventually transforms again into its adult state. made it. But the bounce that night does. And I get a small itchy rash a couple days later that confirms it. [6]

The bounce may appear more quickly after taking TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis or HDCHymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta than it does with NAthe human hookworm, Necator americanus.

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I also experienced a significantly elevated mood that night after taking just 10 HDCHymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta, the elevated mood lasted until the end of the next day. [7]
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I get a nice 'bounce' (from TTOthe ova (eggs) of the human whipworm, Trichuris trichiura) that lasts for about a week...
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My mood was the first indicator that TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis was working. I became calmer and happier despite my physical symptoms. [8]

And there can be differences between the nature of the bounce experienced with each species.

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This (NAthe human hookworm, Necator americanus) bounce differs from the HDCHymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta bounce which made me more energetic (kind of hyperactive). [9]

One advantage of using the organisms that are dosed every couple of weeks (TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis and HDCHymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta, as well as TTOthe ova (eggs) of the human whipworm, Trichuris trichiura which can be taken at similarly frequent intervals) is that this regular dosing regimen can produce a bounce after every dose.

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... every dose of HDCHymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta's is followed by a delightful stream of energy that lasts almost a week. [10]
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I almost always get that lovely 'bounce'. My thinking becomes clearer and my mood becomes calmer and more content. It happens when I top-up with TTOthe ova (eggs) of the human whipworm, Trichuris trichiura or TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis, not as obvious with NAthe human hookworm, Necator americanus. [11]

Unfortunately, for many, the repeat performances are more subdued.

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The first day I take HDCHymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta it usually puts me in a really nice mood, especially the first time I did it. It's not exactly euphoric but I noticed it and counted on it… First time, (it lasted) 48 hours. Second time, 24 hours. Third time, 12 hours. Fourth time, 12 hours.

An ‘anti-bounce’

As can be the case with any infection, a few new helminth hosts may experience an effect opposite to the bounce as their mood falls after inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation].

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I'm now up to day 8 and I'm experiencing the opposite of a bounce: mostly fatigue and an off gut. [12]
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I inoculated with 9 NAthe human hookworm, Necator americanus 7.5 weeks ago. To date I have had very little of the typical initial side effects… Just this low mood setting in around week two or three & getting worse & worse. I'm no stranger to low mood, but this one seems worse that most bouts for me & unusually out-of-the-blue. [13] [14]

The period of low mood can last for a number of weeks and may be repeated after the second dose, but it does gradually improve.

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I took five HWhookworm, usually referring to the human hookworm, Necator americanus and felt pretty depressed at about week seven through to 12. I felt better after that. Six months after my first dose I took another five HWhookworm, usually referring to the human hookworm, Necator americanus and am now at week ten. The depression hasn't been as bad the second time around. Something there but more manageable. [15]
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It went away when I was about to receive my second dose. [16]
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Things felt very black for awhile. Then about 10 weeks after my 2nd inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] my mood turned around and was the best it's been in decades.... [17]

The 'bounce' as predictor of eventual success

There has not been enough detailed feedback to make a firm determination as to whether there is a correlation between the occurrence and strength of the initial bounce and eventual success with the therapy.

One individual has reported a connection between the two in his own case.

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I got a gigantic bounce, and in a few hours went from being incapacitated to tossing back pints of Guinness and played billiards half the night… (then) once the worms matured, several months later, I was a good responder to treatment. [18]

But another was less certain.

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I’d say that, yes, the bounce is a good indication that NAthe human hookworm, Necator americanus will work for you. In terms of whether the bounce is an indication of the extent of the efficacy I would say that it depends on the person but I would suspect no. I got a bounce (of about a day) which was nowhere near as strong as the benefits I've been able to realise. [19]

Long-term improvements in neuropsychiatric function

The neuropsychiatric benefits experienced during the bounce phase can extend into long-term improvements in neuropsychiatric function, as can be seen from the accounts in the Anxiety and Depression sections of the Helminthic therapy personal stories collection, and from comments such as the following.

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What is already interesting is my steady and calm mind. (Reported 6 weeks after inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] with 25 NAthe human hookworm, Necator americanus.)
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I have been depressed most of my life. That eased a bit with IV magnesium. But it changed dramatically about 20 weeks after starting hookwormsA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin.. My mood improved dramatically and I just felt happy - my psychological issues just disappeared. [20]

See also