Hookworm side effects

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A few subjects have mentioned a transient post-inocul...")
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Side effects

The following, mostly transient, side effects have been reported by users of NAthe human hookworm, Necator americanus.

GERD/reflux


A few subjects have mentioned a transient post-inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] increase in stomach acid with heartburn/reflux.

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I rarely suffer gastric reflux but usually do a few days post inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] with NAthe human hookworm, Necator americanus. [1]
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My mother inoculated 5HW for dust mite allergy and atopic dermatitis 2 weeks ago. At one week she started having reflux (never had before). [2]
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I've been having nighmarish GERD symptoms since about week 2, accompanied with horrible belching. [3]
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I inoculated with 10 HWhookworm, usually referring to the human hookworm, Necator americanus at the end of September. I had zero issues and was thinking of doing a second round of ten right away. Then, in the beginning of November I suffered from a massive increase in stomach acid production, which brought on GERD and gastritis type symptoms, along with other GIGastroenterology is the branch of medicine concerned with disorders of the digestive system which includes all the organs of the gastrointestinal (GI) tract (alimentary canal) from mouth to anus. Physicians practicing in this field of medicine are called gastroenterologists or GI specialists. symptoms characteristic of HWhookworm, usually referring to the human hookworm, Necator americanus infection. It was really bad for three weeks. [4]

Joint pain

Joint pain may be experienced by a few, especially when this was a problem prior to inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation].

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My mother inoculated 5HW for dust mite allergy and atopic dermatitis 2 weeks ago. At one week she started having... joint pain (the kind you experience when you have flu, or a fever) and light flu-like fatigue and fever. [5]
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I’ve been on HWhookworm, usually referring to the human hookworm, Necator americanus and WWwhipworm, referring either to the human whipworm, Trichuris trichiura, or the porcine (pig) whipworm, Trichuris suis for 45 days. The first 18 days were easy. Then, on day 19, I was hit with crushing fatigue for eight days…Throughout, I'd been having some joint pain (and have been for years) but it was bearable, but around day 36 the joint pain became awful -- by far the most unpleasant side-effect of the worms I've had yet -- and I'm used to a certain level of joint pain. This is truly horrible. [6]
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At around the 7 week stage I developed strong and scary neuropathic symptoms in my feet and hands. And joint pain especially in my fingers. [7]
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I had painful tingling in my fingers, legs, arms and feet that I described in my journal as "almost like thousands of piranha’s nibbling under my skin." I also noted "a jumpiness that feels cellular". Along with this symptom I also had severe joint pain. Lower back, ankles, neck and one knee. The worst of all of this started around week 8 after my first ever inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] with 5 NAthe human hookworm, Necator americanus. The symptoms finally started to taper off gradually around week 11. I am now at week 14 and all of these sensations are completely gone. [8]

Pelvic pain

One female subject reported pelvic discomfort on days 23 and 24 - not so much a pain as a “menstrual feeling”, as though she was about to start a period. [9]

Neck pain/neck ache

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Before taking helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] i suffered from chronic severe neck pain... When i took my first and so far only dose of NAthe human hookworm, Necator americanus, the neck pain flare up occurred now and then during the initial ten weeks, but it eventually went away. Basically its gone for good as far as i can tell. [10] [11]
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My 10 year old son using 5 HWhookworm, usually referring to the human hookworm, Necator americanus for dog dander allergies experienced neck ache for a short period on day 4 and 5 after inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation]. [12]

Mouth pain

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... mouth pain 3 to 4 weeks after innoculating (25 hwhookworm, usually referring to the human hookworm, Necator americanus). Feels kind of like I burned the roof of my mouth. [13]
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At 6 weeks (post-inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] with NAthe human hookworm, Necator americanus) burned like tongue feeling. Not the roof of the mouth. [14]

Increased food intolerance

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Before HThelminthic therapy, I was only intolerant to dairy and gluten. With my first inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] (5 NAthe human hookworm, Necator americanus) I become intolerant to rice. Now with my second inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] - beans and probably buckwheat... [15]
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Prior to hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. I only had problems with gluten and occasionally dairy. But about 3 weeks after inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] (with 25 larvaeThe active immature form of an insect, or an animal such as a helminth, which develops from an egg and eventually transforms again into its adult state.) I started reacting to what seemed like almost all foods. And at exactly 12 weeks it dropped off and now, at about 15 weeks, I'm fine with all other foods again. [16]

Lightheadedness/reduced blood pressure

Several people have reported a reduction in blood pressure, e.g., [17]

A few have described becoming light headed

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I’ve been lightheaded for a couple of days, especially when standing up, and I've never had that before... I'm a couple weeks in. [18]
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I, too, have had several low blood pressure events recently. I'm 2 1/2 weeks into hosting 25 NAthe human hookworm, Necator americanus. I have gone through several phases in my life when I have gotten dizzy due to low blood pressure. [19]

Recapitulation of old injuries, illnesses

A remarkable side effect phenomenon that can appear following helminth inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] is a "strange, mysterious and magical" recapitulation of symptoms from old injuries and illnesses.

This was reported by someone who inoculated with TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis a few weeks after a bout of pneumonia:

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I took my very first dose of TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis three hours ago (for Hashimoto's and psoriatic arthritis) and my lungs are killing me. Out of nowhere. Really bad pain, almost burning sensation. [20]

Someone who followed two doses of 35 NAthe human hookworm, Necator americanus with a dose of 45, reported that this larger dose triggered a recapitulation of past injuries.

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... the finger I broke last year is killing me, my TMJ is flaring, my knee is all screwy (high school thing), another finger someone hit with a cymbal in high school hurts, and the wrist I broke 28 freaking years ago is acting up. [21]

Other self-treaters using NAthe human hookworm, Necator americanus have had similar experiences.

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My first inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] (5NA) I ended up with weird symptoms I hadn't experienced for YEARS. Full blown reactions. [22]
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The first and second time I dosed with NAthe human hookworm, Necator americanus, I got scared by some disease symptoms I hadn't seen for maybe 10 years. They dissipated after 12 weeks. Now, on my 3rd dose, I'm not having symptoms from 10 years ago but I'm having symptoms I used to have as a child (from 25-30 years ago). [23]
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... then this morning I started having back spasms - real brief intense spasms that hunch me over, knock my breath out, and then are gone. I've had these super randomly in the past (like 3 spasms a year), but I just had 4 within 20 minutes this morning. [24]
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I've been on HThelminthic therapy for 2+ years, so maybe 9 doses (of NAthe human hookworm, Necator americanus). This last time, I felt a heavy, aching soreness all up and down my right arm, and a pain near my elbow. I became seriously alarmed that I might be developing some symptoms of MSMultiple sclerosis (also known as disseminated sclerosis) is a chronic, typically progressive disease involving damage to the sheaths of nerve cells in the brain and spinal cord, whose symptoms may include numbness, impairment of speech and of muscular coordination, blurred vision and severe fatigue. or Parkinson's or something, because it felt like a strain to lift my arm. Then I remembered breaking my right arm at age 9 after a fall from a fast-moving horse. So strange and mysterious and magical to revisit these cellular body memories through the helminth experience. It went away after a couple of days... [25]

Someone else who experienced this phenomenon reported a recapitulation of the pain from all the injuries, and the symptoms of all the diseases that he had ever had, including nerve pain from an auto accident 10 years earlier and an Achilles tendon injury at the age of 8. These all began to appear within a week of his first inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] with NAthe human hookworm, Necator americanus and lasted around a month, causing pain in seemingly every part of his body.

Like other inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] side effects, these mysterious reappearances of old illnesses and injuries don't last very long, and are usually gone within 12 weeks.

Treating the side effects

If necessary, inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] side effects can be quelled completely by taking prednisone/prednisolone. Those who are already taking 20 mg of this drug per day for a preexisting condition will usually not notice any inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] side effects at all, to the extent that they may be convinced the inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] was unsuccessful. However, much smaller amounts of this drug can be equally effective for this purpose.

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… we've found that a half-pill (5 or 10 mg?) of Prednisone per day is enough to kill any of those symptoms from dosing. [26]
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I was having bad diarrhea every day from worm fluThe term commonly used to describe the set of symptoms sometimes experienced initially after inoculation with helminths (especially the hookworm, NA). Some of these symptoms mirror those caused by [https://en.wikipedia.org/wiki/Influenza influenza] - fever, cough, respiratory symptoms, chills, muscle or joint ache, fatigue, abdominal pain, diarrhoea, nausea and vomiting. starting around week three or four. 5mg of prednisone per day helped a lot (I'm 135 pounds). I am in week 7 now and stopped taking prednisone a few days ago (tapered off even though idk if you need to with 5mg) and feel really good. [27]
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5-10 mg/day completely alleviated my GIGastroenterology is the branch of medicine concerned with disorders of the digestive system which includes all the organs of the gastrointestinal (GI) tract (alimentary canal) from mouth to anus. Physicians practicing in this field of medicine are called gastroenterologists or GI specialists. symptoms after my first inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation]... Generally, I prefer non-pharma approaches to managing my health but was really thankful for prednisone mitigate the side effects of my first dose of NAthe human hookworm, Necator americanus. It made the difference between whether or not I could get off of the couch and function throughout the day. [28] (This quote includes additional details from an expired link.)

A short course of prednisone immediately following inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] can be particularly helpful for anyone with an intestinal stricture. The drug will obviate the possibility of localised inflammation making a stricture worse. Prednisone may also be appropriate if diarrhoea or fatigue persist for more than a few days, and it could be continued for a week, with a doctor's approval, followed by a taper agreed by the doctor.

Anyone who is worried about inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] side effects could ask their doctor for a prescription for prednisone and keep this on hand for use in suppressing the side effects if these were to become troublesome. As it should only be needed for a short time, there would be no long term adverse consequences of taking this drug.

As all the side effects are related to inflammation, anything that reduces inflammation could potentially help. The side effect mechanism is very similar to allergies, so antihistamines may help and many subjects have reported good results with this type of drug. However, only worm-safe antihistamines listed in the Human helminth care manual should be used.

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Allergy medication helped me more than anything else because it calmed down my reaction. [29]
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Fexofenadine tempers the (epigastric) pain almost the entire day. [30]
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Taking Benadryl (antihistamine in US) has helped a lot and keeps the (stomach) pain away for the most part. I take it several times a day. [31]

Low dose Naltrexone also looks promising as a means of offsetting symptoms during this side-effect phase, and diarrhoea usually responds well to a standard diarrhoea relief preparation such as loperamide.

In theory, ibuprofen should work well, as it is an anti-inflammatory but, in practice, it is unlikely to help and may even make things worse. Like Naprosen, and other NSAIDs, ibuprofen is notorious for being hard on the stomach and gut. ParacetamolAcetaminophen (Tylenol) might be better.

Of course, none of this is medical advice, and drugs like prednisone are prescription-only medications that should only be used with the guidance of a doctor.

Only in the most severe cases will it be necessary to terminate a hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. infection and start over with a smaller dose.

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