Difference between revisions of "Helminthic therapy for well people"

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(Parkinson's disease: Added a citation.)
(Added an HIV section and the first citation in this.)
 
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* [http://trjfas.org/uploads/pdf_1183.pdf Role of Parasitic Helminths in Bioremediating Some Heavy Metal Accumulation in the Tissues of Lethrinus mahsena]
 
* [http://trjfas.org/uploads/pdf_1183.pdf Role of Parasitic Helminths in Bioremediating Some Heavy Metal Accumulation in the Tissues of Lethrinus mahsena]
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====HIV====
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Helminth infections can reduce the susceptibility of T-cells to HIV-1 infection, so may be beneficial against HIV-1.
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*[https://www.ncbi.nlm.nih.gov/pubmed/31487324 Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro] -- [https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007924 Full text]
  
 
====Hyperemesis gravidarum====
 
====Hyperemesis gravidarum====

Latest revision as of 20:32, 7 September 2019

Home>Effects of helminthic therapy>Helminthic therapy for well people

Home>HT research>Helminthic therapy for well people

We refer to the deliberate hosting of helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] as a therapy, but it is more than this. Evolution has determined that having a helminthAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths]-rich microbiotaThe specific population of microorganisms living in a certain part of the body, such as the gut. "Microbiome" refers to all the microorganisms living in and on the body, or the genome of these microorganisms. These two terms are often used interchangeably. is the default state for humans, and it is already clear that there are many benefits to be gained from hosting helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] throughout life, even for people in apparently good health. This approach views helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] as being more like vitamins, and their absence as a helminth deficiency. Almost all who are living in industrialised countries today are helminthAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths]-deficient.

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I think eventually, we’ll understand that helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] are just a normal part of the ecosystem of our body. And eventually, I think it’s going to go beyond just a therapy. I think it’ll be a kind of probioticMicroorganisms that are believed to provide health benefits when consumed. that people will be using just to maintain health.
(William Parker, Duke University.)

Since helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] are very effective in reducing inflammation, maintaining a small colony of helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] could potentially help to prevent a whole slew of degenerative diseases and other conditions related to the silent, chronic, low-grade, systemic inflammation that exacts a relentless toll on our tissues. [1]

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All immunocompetent humans need regular exposure to helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] in order to maintain optimal immune function and avoid risk for inflammation-associated disease. This conclusion is based on “biota alteration theory”, the view that loss of biodiversity from the ecosystem of the human body as a result of industrialization has contributed to increased immune dysregulation and non-adaptive inflammation. In this view, exposure to helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] is a necessary component of our biology, and the essentially complete absence of those organisms is an underlying cause of inflammatory disease. Based on this view, we have argued that access to helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] is a basic human need. (Smyth et al, 2017)

There is mounting evidence to support this view, as can be seen from the following papers and articles.


Potentially reducible health risks

Allergy

Alopecia areata

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We have seen a link between AA and a dysfunctional gastrointestinal system which raised the hypothesis that an underlying intestinal inflammation drives the priming and dysregulation of immune cells that lead to hair follicle destruction. [2]
  • Mechanisms of tolerance and potential therapeutic interventions in Alopecia Areata -- Full text | PDF (See section 4: Gut microbiotaThe specific population of microorganisms living in a certain part of the body, such as the gut. "Microbiome" refers to all the microorganisms living in and on the body, or the genome of these microorganisms. These two terms are often used interchangeably. and helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths], autoimmunity and tolerance.)

Alzheimer’s disease

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We present evidence that the E4 allele, often associated with cognitive decline, ADAncylostoma duodenale. A species of roundworm, aka the Old World hookworm, that is not suitable for use in helminthic therapy. [https://en.wikipedia.org/wiki/Ancylostoma_duodenale Wikipedia:Ancylostoma duodenale], and CVD in industrialized populations with minimal parasiteAn organism that lives in or on another organism (its host) and benefits at the host’s expense. (The organisms used in helminthic therapy are, strictly speaking, not parasites, but mutualists, because they have a mutually beneficial symbiotic relationship with their hosts.) burden, was associated with higher cognitive function among Tsimane Amerindians, but only among individuals with evidence of high parasiteAn organism that lives in or on another organism (its host) and benefits at the host’s expense. (The organisms used in helminthic therapy are, strictly speaking, not parasites, but mutualists, because they have a mutually beneficial symbiotic relationship with their hosts.) burden.

Arthritis

Atherosclerosis

Chronic helminth infection may protect against atherosclerosis development via induction of anti-inflammatory responses and alteration of atherogenic biomarkers.

Autoimmune disease

The following paper reveals that exposure to stress might lead to the development of autoimmune disease, and it could be argued that the powerful anti-inflammatory effects of helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] might help to interrupt this progression and reduce the risk of someone with a stress-related disorder going on to develop autoimmunity.

Autism

When a mother's immune system is modulated by helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] during pregnancy, her children will likely have a reduced risk of developing autism.

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Given the vast body of scientific literature connecting impaired cognitive development and function with inflammation, it seems almost certain that normalization of immune function and reduction of inflammatory disease in the human population will result in dramatically decreased levels of a wide range of cognitive disorders, including autism. [3]

Bone healing ability, loss of in the elderly

Age-associated inflammation is responsible for the decline in the number and function of the skeletal stem cells that enable bones to heal.

Cancer

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… specific pathogens may be able to elicit anti-tumor immune responses that can lead to protection from tumorigenesis or cancer regression.

Also see Helminthic therapy and cancer.

Cardiovascular disease

Nearly half of all adult Americans have cardiovascular disease. [4]

Immunotherapies that treat inflammatory conditions might have a role in the reduction of cardiovascular disease risks, [5] and anti-inflammatory medication allows patients with a history of heart attacks to enjoy a significantly lower incidence of recurrent cardiovascular events, [6] but these drugs may only be necessary because of the helminth deficiency that is widespread thought the developed world in the twenty first century.

Chronic Obstructive Pulmonary Disease (COPD)

COPD is a group of diseases that cause airflow blockage and breathing-related problems, including emphysema and chronic bronchitis.

Infection with a human hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin.-like helminthAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths], Nippostrongylus brasiliensis, briefly initiates the onset of emphysematous pathology, but this is quickly reversed by helminthAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths]-induced regulatory mechanisms that promote tissue repair and mitigate the emphysema.

Cognitive dysfunction

Dementia

Depression

Diabetes

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Abundant evidence indicates that helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] and their by-products can exert immunomodulatory effects that prevent or delay the onset of T1D.… In the future, helminthAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths]-derived supplements may be included as part of a modern balanced diet.
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Helminth infections… may be protective against the development of diabetes, and this finding opens up new territory for discovery of novel therapeutics for the prevention and treatment of diabetes.
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… methods designed to suppress excess production of pro-inflammatory cytokines may form a new approach to prevent both type 1 and type 2 diabetes mellitus.

Also see Helminthic therapy and diabetes.

Encephalitis

Encephalitis, or brain inflammation, causes fever, confusion, memory loss, psychosis and seizures. It can progress quickly over weeks or even days and may become life-threatening.

Whether this condition is caused by infection or autoimmunity, a helminth deficiency will arguably increase the risks, whereas helminth exposure may reduce them.

Fibromyalgia

Fibromyalgia has been linked to increased systemic inflammation and neuro-inflammation.

Glaucoma

Graves' disease

Graves’ hyperthyroidism may be prevented by helminth infection or with the application of helminthAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths]-derived products.

Helicobacter pylori infection

Hosting intestinal helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] may provide a buffering mechanism against the effects of H. pylori infection, alleviating the Th1-dependent response and protecting against inflammation within the gastrointestinal tract.

Heavy metal accumulation

Some helminth species may be able to remediate heavy metal accumulation in their hosts’ tissues.

HIV

Helminth infections can reduce the susceptibility of T-cells to HIV-1 infection, so may be beneficial against HIV-1.

Hyperemesis gravidarum

Hyperemesis gravidarum (HG) is a pregnancy complication characterised by severe nausea, vomiting, weight loss, and possibly dehydration, [7] which is considered more severe than morning sickness. [8] In view of the fact that allergy is the most significant condition associated with HG prior to pregnancy [9] - which suggests a possible allergic or autoimmune component - it is possible that women who are hosting helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] might be less likely to develop HG.

Immune disorders

Inflammatory bowel disease (IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC).)

Helminth exposure may prevent IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC)..

Insulin resistance

Helminth infections are associated with lower insulin resistance.

Joint replacement, failure of

HelminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] could extend the life of joint replacements by reducing inflammation-related bone loss.

Kidney pathology

A worm-derived immunomodulator protects against kidney damage in SLE.

Leg ulcers, recalcitrant

Research has identified a connection between wounds that don't heal and autoimmunity, suggesting that preventing autoimmune disease by hosting helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] might also help to reduce the risk of recalcitrant leg ulcers.

Lifespan reduction

Macular degeneration / age-related macular degeneration (AMD)

Malaria

Children with helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] may be less likely to contract malaria.

Infection by Trichuris trichiuraThe human whipworm used in helminthic therapy and taken periodically as microscopic eggs (TTO) in a drink. has been associated with direct reductions in cerebral malaria risk.

Removal of helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] can increase the risk from infectious agents such as malaria and influenza.

Hosting hookwormsA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. concurrently with one species of malaria can reduce the malaria burden by almost 50 percent.

Miscarriage

Many women who suffer recurrent miscarriages exhibit autoimmune phenomena similar to what is seen in patients with Systemic Lupus Erythematosus (SLE), and these women may be treated with prednisone to reduce inflammation.

Also see Helminthic therapy and pregnancy.

Muscle mass loss in the elderly

Age-related decline in muscle function may be driven by chronic inflammation.

Narcolepsy

Also see Helminthic therapy and narcolepsy.

Neuropsychiatric disorders

Exposure to helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] may have a profoundly positive affect on neuropsychiatric disorders. [10] [11] HDCsHymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta are already being used effectively as a therapeutic agent to relieve a wide range of these disorders, [12] (PDF) [13] [14] and Bilbo and colleagues have used a laboratory model to show that colonization with H. diminutaA murine (rat) tapeworm used in helminthic therapy that generally does not mature in humans and is taken as cysticerci (HDC) in a drink every 2 or 3 weeks. protects rats from inflammation-induced cognitive dysfunction. [15]

Obesity

HelminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] prevented weight gain in laboratory mice on a high-fat diet. They did this by boosting populations of bacteria that produce compounds which trigger increased energy consumption.

Obsessive-compulsive disorder (OCD)

Obstructive sleep apnea

Osteoarthritis

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… initially considered cartilage driven, OA is a much more complex disease with inflammatory mediators released by cartilage, bone and synovium. Low-grade inflammation induced by the metabolic syndrome, innate immunity and inflammaging are some of the more recent arguments in favor of the inflammatory theory of OA…”

Osteoporosis

Pain, chronic

Parkinson's disease

Chronic inflammation may cause neurodegeneration in Parkinson's disease.

Parkinson's disease may originate in the intestines.

The use of immunosuppressant drugs may keep Parkinson's disease at bay, and may also slow progression of the disease if it develops.

HelminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] can achieve similar beneficial effects to immunosuppressants without the long term adverse side effects.

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They (pig whipwormsA helminth with a tapering whiplike body that lives in the colon. In helminthic therapy, the microscopic eggs of either the human Trichuris trichiura (TTO) or pig Trichuris suis (TSO) are taken in a drink. - TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis) have a brilliant effect on dyskinesia and the need for drugs. It reduces the need for levadopa considerably. [16] (Video)

Also see Helminthic therapy and Parkinson's disease.

Preeclampsia

Also see Helminthic therapy and pregnancy.

Premature birth

Premenstrual Syndrome

(Science Alert have published a very readable article about this research.)

Psychosis

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There are several lines of evidence to suggest that a proportion of psychotic illnesses have a plausible autoimmune component.

Rheumatoid arthritis (RA)

Rosacea

The risk for rosacea, as well as other skin disorders such as atopic eczema and onychomycosis (toenail fungus), increase with the presence of systemic low-grade inflammation.

Schizophrenia

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Inflammation, particularly of a low-grade nature, is a consistent pathological finding in schizophrenia… [17] [18]

Sepsis

A helminthAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths]-derived molecule significantly suppressed the inflammation-driven cytokine storm in a mouse model of septic shock.

Suicide

Tourette Syndrome

Tuberculosis

Venous thromboembolism (VTE)

(Also pulmonary embolism (PE) and deep vein thrombosis (DVT)).

Inflammation appears to change the hemostatic balance towards thrombogenesis, and autoimmune disorders have been linked to an increased risk of VTE.

A testimony to health enhancement

Well people who host helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] as prophylaxis against autoimmune and inflammation-related conditions may never know exactly how much their worms have helped to keep them well but, occasionally, a case is reported that hints at the extent of the potential benefits.

When a clinical pathologist specialising in medical microbiology heard about helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy., he decided he had to experience what was involved, but he had no expectation of benefit beyond hoping that it might possibly improve his seasonal hay fever. In the event, he experienced several additional benefits.

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Unexpected was the disappearance of the arthritis in my knees, being able to go for a jog without having to stop out of breathlessness (I think I must have had undiagnosed exertional asthma all my life), and finding myself unattracted by starchy, greasy foods. Result of the latter being that I have lost 12 Kg, and kept it off, and that is after 65 years of unsuccessfully battling overweight! Going with that, my total to HDL cholesterol ratio has fallen from 4.3 to 2.8. [19] I've had no recurrence of the painful heels of plantar fasciitis, and… best of all, my mood has improved hugely. I am a really happy person. [20]

See also