Difference between revisions of "Helminthic therapy and scleroderma"

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m (A cautionary note about the use of hookworms in scleroderma patients with associated lung complications.)
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* [[Helminthic therapy personal stories#Mixed connective tissue disease (MCTD) | '''Helminthic therapy personal stories: Mixed Connective Tissue Disease (MCTD)''']]
 
* [[Helminthic therapy personal stories#Mixed connective tissue disease (MCTD) | '''Helminthic therapy personal stories: Mixed Connective Tissue Disease (MCTD)''']]
  
===A cautionary note about the use of hookworms in scleroderma patients with associated lung complications.===
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===A cautionary note about the use of hookworms in scleroderma patients with associated lung diseases===
  
 
Anyone with pulmonary complications associated with scleroderma who wishes to try helminthic therapy using hookworms should adopt a very conservative approach to dosing to avoid the possibility of developing Loffler’s syndrome. See [[Hookworm dosing and response#Too many hookworms may cause Löffler’s (Loeffler's) syndrome | '''Too many hookworms may cause Löffler’s (Loeffler's) syndrome''']].
 
Anyone with pulmonary complications associated with scleroderma who wishes to try helminthic therapy using hookworms should adopt a very conservative approach to dosing to avoid the possibility of developing Loffler’s syndrome. See [[Hookworm dosing and response#Too many hookworms may cause Löffler’s (Loeffler's) syndrome | '''Too many hookworms may cause Löffler’s (Loeffler's) syndrome''']].
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One patient with lung diseases associated with scleroderma (pulmonary hypertension and interstitial lung disease), who had enjoyed significant benefits after initial doses of 5 and 10 NA, then developed Loffler’s syndrome following a subsequent dose of 15 NA. She went into right heart failure requiring admission to hospital, termination of her hookworm colony and a course of high dose prednisone. [https://www.facebook.com/michael.mcevoy.3557/posts/10158246226984281?comment_id=10158427499019281] [https://www.facebook.com/groups/SclerodermaFM/permalink/4007255586016189/?comment_id=4007321356009612&reply_comment_id=4007335692674845]  
 
One patient with lung diseases associated with scleroderma (pulmonary hypertension and interstitial lung disease), who had enjoyed significant benefits after initial doses of 5 and 10 NA, then developed Loffler’s syndrome following a subsequent dose of 15 NA. She went into right heart failure requiring admission to hospital, termination of her hookworm colony and a course of high dose prednisone. [https://www.facebook.com/michael.mcevoy.3557/posts/10158246226984281?comment_id=10158427499019281] [https://www.facebook.com/groups/SclerodermaFM/permalink/4007255586016189/?comment_id=4007321356009612&reply_comment_id=4007335692674845]  
  
Others with lung issues associated with scleroderma might therefore wish to adopt a much more gradual increase in the size of NA doses, and lengthen the intervals between doses.
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Others with lung issues associated with scleroderma might therefore wish to adopt a much more gradual increase in the size of NA doses, and perhaps lengthen the intervals between doses.

Revision as of 18:31, 26 June 2020

Home>Effects of helminthic therapy>Helminthic therapy and scleroderma

Scleroderma is a disease that may only exist because of an absence of helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths].

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The missing communication cues from the helminth to the mammalian host can cause exacerbated and uncontrolled immune responses, which in turn can cause widespread vasculopathy and fibrosis, including the pulmonary arteries. It follows that treatment with medical helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths]… could provide novel means of intervention for SSc, SSc- associated pulmonary hypertension, and other autoimmune connective tissue diseases. [1]

For reports of success using helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. to treat scleroderma, see the following page section.

The following resounding success was reported in a private message from an individual with MCTD - a crossover syndrome that includes components of scleroderma, dermatomyositis and polymyositis, as well as lupus - who had been on hydroxychloroquine and prednisone for 5 years.

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The worms have been working for me. I have been in drug free remission for over 3 months now, I hypothesize that other lupus-spectrum disorders will respond similarly. After all, HLA-B27 is an autoimmune marker that is shared by inflammatory bowel disease as well as lupus/MCTD.

There are reports from other individuals with MCTD in the following page section.

A cautionary note about the use of hookwormsA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. in scleroderma patients with associated lung diseases

Anyone with pulmonary complications associated with scleroderma who wishes to try helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. using hookwormsA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. should adopt a very conservative approach to dosing to avoid the possibility of developing Loffler’s syndrome. See Too many hookworms may cause Löffler’s (Loeffler's) syndrome.

One patient with lung diseases associated with scleroderma (pulmonary hypertension and interstitial lung disease), who had enjoyed significant benefits after initial doses of 5 and 10 NAthe human hookworm, Necator americanus, then developed Loffler’s syndrome following a subsequent dose of 15 NAthe human hookworm, Necator americanus. She went into right heart failure requiring admission to hospital, termination of her hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. colony and a course of high dose prednisone. [2] [3]

Others with lung issues associated with scleroderma might therefore wish to adopt a much more gradual increase in the size of NAthe human hookworm, Necator americanus doses, and perhaps lengthen the intervals between doses.