Difference between revisions of "Helminthic therapy and pregnancy"

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==See also==
==See also==

* [[Helminthic therapy and fertility | '''Helminthic therapy and fertility''']]
* [[Helminthic therapy and breastfeeding | '''Helminthic therapy and breastfeeding''']]
* [[Helminthic therapy and breastfeeding | '''Helminthic therapy and breastfeeding''']]
* [[Helminthic therapy and children | '''Helminthic therapy and children''']]
* [[Helminthic therapy and children | '''Helminthic therapy and children''']]

Revision as of 18:42, 10 March 2019

Home>Effects of helminthic therapy>Helminthic therapy and pregnancy
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Hosting helminths during pregnancy is commonplace, with approximately 44 million pregnancies occurring globally each year in women with helminths. [1]

De-worming during pregnancy is not advantageous and may be harmful[edit]

Many medics have advocated de-worming pregnant women to prevent a range of supposed health risks, but studies have found that, where good antenatal care is provided, de-worming produces no benefits in respect of anaemia, birth weight, perinatal mortality, infant mortality or infant response to immunisation. [2] [3] [4]

Deworming did not show consistent benefits for indicators of mortality, anemia, or growth in children younger than five or women of reproductive age. [5]
… anthelmintic treatment during pregnancy has no benefit for an infant's response to immunisation, or for their health and development… [6]
... treatment may impose more costs than benefits, for example, by increasing the risk of infant eczema. Treatment may also have additional unanticipated effects by altering maternal blood glucose regulation, microbiota, or hormonal environment. [7]

Both mother and child benefit when helminths are hosted during pregnancy[edit]

Prenatal exposure to parasite antigens impacts on the strength and width of postnatal immune responsiveness without generating aberrant inflammatory immune responses. Neonates not exposed to parasite antigens have inappropriately increased or decreased gene expression profiles. [8]

Current epidemiological findings suggest that prenatal exposure to helminth infection may have an important effect on the development of the foetal immune response and that this might help prevent the emergence of inflammatory conditions such as allergy. [9]

The presence of helminths at delivery has been shown to be inversely related to infantile eczema, supporting the hypothesis that maternal helminth infection protects against this disease. [10]

Studies in mice indicate that helminth infection during pregnancy may reduce the susceptibility of the offspring to allergic airway inflammation. [11] [12]

Helminth infection in the perinatal period protects children from the neurological damage that can accompany bacterial infections, and this protection extends into adulthood. [13]

Antenatal maternal helminth infections are associated with modestly increased IgA responses to oral infant vaccines. [14]

Sepsis, a condition that is hard to recognise and treat, is an increasing cause of complications and death among women in the West, and rates of severe and fatal sepsis during labor and delivery are rising sharply, such that sepsis is now the leading cause of direct maternal death in the UK. [15]

As a helminth infection counterbalances the exacerbated pro-inflammatory immune responses that occur during sepsis, thus improving survival, it is arguable that the presence of a small colony of therapeutic helminths might actually prevent a woman developing sepsis. [16]

Hyperemesis gravidarum (HG) is a pregnancy complication characterised by severe nausea, vomiting, weight loss, and possibly dehydration, [17] which is considered more severe than morning sickness. [18] In view of the fact that allergy is the most significant condition associated with HG prior to pregnancy [19] - which suggests a possible allergic or autoimmune component - it is possible that women who are hosting helminths might be less likely to develop HG.

Since helminths control inflammation, commencing helminthic therapy prior to pregnancy might help women who have autoimmune disorders such as colitis to stay healthy during pregnancy, [20] and help to spare their offspring adverse, inflammation-related effects on brain development, some of which can result in autism-like features. [21] [22]

I am a physician and see absolutely no problem with using HT while pregnant. In fact, I plan to do it myself later this year. (Posted to a Helminthic Therapy support group.)

Reports by women who hosted a small number of helminths while pregnant[edit]

One woman who examined all the available evidence on the risks and benefits of hosting helminths during pregnancy came to the following conclusion.

I got hookworm (and just a couple of whipworms) to help keep my immune system in check during my next pregnancy, since my first kid is on the autism spectrum. From my research it seems safe in low doses and can prevent allergy in offspring, another reason I decided to go for this. Not pregnant yet, just planning.

And she reported, at a later date,

I hosted whipworm and hookworm during 2 term pregnancies. The first baby is 2 years old and is free of allergies and autoimmunity, unlike the older sibling who was sick since birth.

Someone else, who had previously had two children with severe eosinophilic esophagitis-related food intolerances, maintained a hookworm colony throughout her next pregnancy and delivered a healthy, allergy-free baby. [23]

Another mother has reported,

I hosted hookworm while pregnant with my second and had no issues. [24]

Mothers, as well as their babies, can benefit by continuing to host helminths during their pregnancy.

In June of 2016 I decided to try TSO 2500 every 2 weeks, and for the first time, had some real improvement in my (RA-related) inflammation and pain. I got pregnant in September 2016 and from my own research and from talking to Tanawisa, I felt comfortable continuing with the TSO throughout my pregnancy. Because uncontrolled inflammation in a pregnant mother has been proven so detrimental to the health of the child, I decided to bump up my dose of TSO to 2500 every week. Throughout my pregnancy I have had almost no inflammation or joint pain, except for a couple of small flare ups during some stressful events. [25] (This mother also reported, in a different Facebook group, that her baby is healthy.)

The question of whether to introduce helminths during pregnancy[edit]

Notwithstanding the benefits to be gained by establishing a helminth colony before becoming pregnant, and the lack of any indication that the organisms currently used in helminthic therapy can harm a developing foetus, the possible risks of commencing helminthic therapy for the first time during pregnancy are unknown, and two hookworm hosts have commented as follows:

If it were me, I would feel comfortable infecting myself with helminths for the first time before a pregnancy but not during. [26]
I made the decision not to inoculate during either of my pregnancies - the first because I didn't have an existing colony and I was worried about the heightened immune response triggering heightened immune responses in my child as well as my ability to take any medications to manage the side effects; the second because I already had an existing colony and felt well enough that I was happy to wait. [27]

If a woman were to start helminthic therapy while pregnant, and have a miscarriage, or encounter a problem with the new baby, they, or their healthcare providers, might blame the helminths, and legal action could be taken against whoever supplied them. Since providers of therapeutic helminths must act with this possibility in mind, they would be very unlikely to supply helminths to anyone who is already pregnant.

Five of the helminth providers recommend waiting until after pregnancy before starting helminthic therapy.

In lack of appropriate clinical studies, this supplement should, however, not be taken during pregnancy. (Tanawisa)
If you are pregnant or planning on becoming pregnant soon after starting therapy we will not provide hookworm to you. (Autoimmune Therapies)
Since, this therapy is so new we do not know the effects on the fetus so we do not treat women who are pregnant. (Worm Therapy)
Due to a lack of clinical research we would not recommend the treatment for pregnant women. (Wormswell)
Due to the lack of clinical data, anyone who is pregnant would need to wait until after the child is born before beginning the treatment. (Symmbio)

And one provider recommends supervision by a physician.

If someone wishes to begin to restore their biome while pregnant, they should do so under a physician’s supervision. (Biome Restoration)

Note: if a woman who fell pregnant while hosting human helminths wished to terminate the colony, it had been suggested that it would be best to avoid using mebendazole for this purpose. However, a study in 2016 found no association between exposure to mebendazole at any time during pregnancy and negative birth outcomes. [28]

Discussion threads about helminths and pregnancy[edit]

1. Pregnancy and hookworms. Sept 2010. [29]

2. Thinking of inoculating while pregnant. Aug/Sept 2011. [30]

3. Experiences of pregnancy as a current or recent helminth host. Sept 2013. [31]

4. A doctor’s concern about a hookworm-hosting pregnant patient. Dec 2016. [32]

See also[edit]