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{{Breadcrumb|[[Effects_of_helminthic_therapy|Effects of helminthic therapy]]}}
{{Breadcrumb|[[Effects_of_helminthic_therapy|Effects of helminthic therapy]]}}
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|title=
|title=Helminthic therapy and neuropsychiatric function
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All four species of therapeutic helminth appear to be capable of improving neuropsychiatric function.
Helminths are capable of improving neuropsychiatric function, and all four species of therapeutic helminth appear to make a positive contribution to psychological wellbeing.
 
{{Quote|indent}}Socio-medical studies of humans "self-treating" with helminths as well as limited studies in animal models strongly suggest that helminth therapy may be a productive approach toward treating a range of neuropsychiatric disorders, including chronic fatigue, migraine headaches, depression and anxiety disorders. [https://www.ncbi.nlm.nih.gov/pubmed/29402395]{{Quote|/indent}}
 
Additional supporting research includes the following paper.
 
* [https://www.ncbi.nlm.nih.gov/pubmed/31352539 Potential application of helminth therapy for resolution of neuroinflammation in neuropsychiatric disorders]<br><br>
 
==Depression==


===Reduced depression / improved mood===
===Reduced depression / improved mood===


HDC is mentioned a lot in this context, and William Parker’s team at Duke University are proposing to test its effect on depression.
HDC is mentioned a lot in this context, and, since HDC is taken regularly, usually every 2 weeks, its users can benefit from a repeated post-inoculation [[The helminthic therapy bounce | 'bounce’]]. This is a brief period of temporary symptom relief accompanied by a sudden feeling of unusual wellness, perhaps with a strong sense of calm, focus, happiness and lightheartedness.  
* [http://www.dukechronicle.com/article/2015/09/duke-scientists-treat-depression-with-intestinal-worms Duke scientists treat depression with intestinal worms]
 
Since HDC is taken regularly, usually every 2 weeks, its users can benefit from a repeated post-inoculation [[The helminthic therapy 'bounce' | 'bounce’]], which is a brief period of temporary symptom relief accompanied by a sudden feeling of unusual wellness, perhaps with a strong sense of calm, focus, happiness and lightheartedness.  


{{Quote|indent}}I like how it puts me in a good mood for a day or two when I first take it.{{Quote|/indent}}  
{{Quote|indent}}I like how it puts me in a good mood for a day or two when I first take it.{{Quote|/indent}}  
Line 28: Line 33:
{{Quote|indent}}The first day I take HDC it usually puts me in a really nice mood, especially the first time I did it. It's not exactly euphoric but I noticed it and counted on it… First time, (it lasted) 48 hours. Second time, 24 hours. Third time, 12 hours. Fourth time, 12 hours.{{Quote|/indent}}
{{Quote|indent}}The first day I take HDC it usually puts me in a really nice mood, especially the first time I did it. It's not exactly euphoric but I noticed it and counted on it… First time, (it lasted) 48 hours. Second time, 24 hours. Third time, 12 hours. Fourth time, 12 hours.{{Quote|/indent}}


However, this effect on neuropsychiatric function is not unique to HDC, and is also seen with TSO and NA.
However, this effect on neuropsychiatric function is not unique to HDC. It is also seen with TSO, NA and TTO.


{{Quote|indent}}My mood was the first indicator that TSO was working. I became calmer and happier despite my physical symptoms. [https://www.facebook.com/groups/htsupport/permalink/861668620555761/?comment_id=862075060515117&offset=0&total_comments=13&comment_tracking=%7B%22tn%22:%22R%22%7D]{{Quote|/indent}}   
{{Quote|indent}}My mood was the first indicator that TSO was working. I became calmer and happier despite my physical symptoms. [https://www.facebook.com/groups/htsupport/permalink/861668620555761/?comment_id=862075060515117&offset=0&total_comments=13&comment_tracking=%7B%22tn%22:%22R%22%7D] I find TSO is the best for mood and general feeling of well being as well as increased energy. Hookworm and (human) whipworm both work as well, it just takes longer. [https://www.facebook.com/groups/htsupport/permalink/1620673674655248/?comment_id=1666993650023250&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote|/indent}}   


{{Quote|indent}}My daughter started TSO last week and we are already seeing an improvement in her mood and energy on a low dose of 500 ova. [https://www.facebook.com/groups/htsupport/permalink/862879650434658/?comment_id=862906407098649&offset=0&total_comments=3&comment_tracking=%7B%22tn%22:%22R%22%7D]{{Quote|/indent}}   
{{Quote|indent}}My daughter started TSO last week and we are already seeing an improvement in her mood and energy on a low dose of 500 ova. [https://www.facebook.com/groups/htsupport/permalink/862879650434658/?comment_id=862906407098649&offset=0&total_comments=3&comment_tracking=%7B%22tn%22:%22R%22%7D]{{Quote|/indent}}   
{{Quote|indent}}TSO cured a mood disorder I didn't realize I had until it was gone. [https://www.facebook.com/groups/htsupport/posts/4461359747253279/]{{Quote|/indent}}<!-- Laurel Fitzhugh -->
{{Quote|indent}}I would like to confirm positive effect of TSO on mood stabilization as well. Even with low dose in my case (300 ova bi-weekly). [https://www.facebook.com/groups/htsupport/posts/4461359747253279/?comment_id=4464894023566518]{{Quote|/indent}}<!-- Nataška Dekanová -->


The following comment was made 6 weeks after inoculation with 25 hookworm larvae.
The following comment was made 6 weeks after inoculation with 25 hookworm larvae.
Line 38: Line 47:
{{Quote|indent}}What is already interesting is my steady and calm mind.{{Quote|/indent}}
{{Quote|indent}}What is already interesting is my steady and calm mind.{{Quote|/indent}}


For further accounts of how helminthic therapy has reduced depression - mostly from users of NA - see the following page section.
For further accounts of how helminthic therapy has reduced depression, see the following.
* [[Helminthic therapy personal stories#Depression/low mood | '''Helminthic therapy personal stories: Depression / low mood''']]
* [[Helminthic therapy personal stories#Depression/low mood | '''Helminthic therapy personal stories: Depression / low mood''']]
* [https://www.ncbi.nlm.nih.gov/pubmed/27240605 Practices and outcomes of self-treatment with helminths based on physicians' observations] -- [[media:Practices_and_outcomes_of_self-treatment_with_helminths_based_on_physicians_observations.pdf | PDF]] (In particular, see Table 1)


===Temporarily ''increased'' depression===
===Temporarily ''increased'' depression===


Occasionally, depression may increase temporarily following initial inoculation with helminths, but this is often dose-related.
Occasionally, depression may increase temporarily following initial inoculation with helminths. This is usually, but not necessarily, the result of using doses that are too high.


{{Quote|indent}}After first small group of NA, I became much more depressed for about 10-12 weeks, then got back to previous mood level. [https://www.facebook.com/groups/htsupport/permalink/1526355860753697/?comment_id=1526618564060760&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote|/indent}}
{{Quote|indent}}After first small group of NA, I became much more depressed for about 10-12 weeks, then got back to previous mood level. [https://www.facebook.com/groups/htsupport/permalink/1526355860753697/?comment_id=1526618564060760&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote|/indent}}
{{Quote|indent}}I have hit a patch of depression here at week 9 of my first inoculation with 3NA and I am feeling very bleak. [https://www.facebook.com/groups/htsupport/permalink/1814806755241938/]{{Quote|/indent}}
{{Quote|indent}}I also feel quite depressed, will be 9 weeks for me on Tuesday. [https://www.facebook.com/groups/htsupport/permalink/1814806755241938/?comment_id=1815580378497909&comment_tracking=%7B%22tn%22%3A%22R0%22%7D]{{Quote|/indent}}
{{Quote|indent}}After first small group of NA, I became much more depressed for about 10-12 weeks, then got back to previous mood level. [https://www.facebook.com/groups/htsupport/permalink/1526355860753697/?comment_id=1526618564060760&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote|/indent}}
A few individuals experience increased depression after ''every'' dose of hookworms, especially if the doses contain too many larvae.
{{Quote|indent}}3.5 years in, I now have times where I even feel positive and optimistic, which is a huge improvement over a lifetime of clinical depression. But it’s also the first symptom to return, especially if I take a dose of NA that’s a little too much. Last dose was 7, and 3 days later I started 9 days of deep despair. I know it’s temporary, so I just hang on and get through it, but now I know 7 is too many. [https://www.facebook.com/groups/htsupport/permalink/1936169449772334/?comment_id=1936702619719017&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote|/indent}}
{{Quote|indent}}I experience plummeting mood following an NA inoculation. Dosing amounts are important with NA. [https://www.facebook.com/groups/htsupport/permalink/1936169449772334/?comment_id=1936702619719017&reply_comment_id=1936765523046060&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote|/indent}}
==Anxiety==


===Reduced anxiety===
===Reduced anxiety===
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The potential for helminths to reduce anxiety can be seen in the reports in the following page section.
The potential for helminths to reduce anxiety can be seen in the reports in the following page section.
* [[Helminthic therapy personal stories#Anxiety | '''Helminthic therapy personal stories: Anxiety''']]
* [[Helminthic therapy personal stories#Anxiety | '''Helminthic therapy personal stories: Anxiety''']]
And in this paper. (See Table 1 in particular.)
* [https://www.ncbi.nlm.nih.gov/pubmed/27240605 Practices and outcomes of self-treatment with helminths based on physicians' observations] -- [[media:Practices_and_outcomes_of_self-treatment_with_helminths_based_on_physicians_observations.pdf | PDF]]


===Temporarily ''increased'' anxiety===
=== Temporarily ''increased'' anxiety===


There have been a few reports of anxiety increasing temporarily following the initial inoculation with NA, TTO and HDC. This can be dose-related.
There have been a few reports of anxiety increasing following initial inoculation with NA, TTO or HDC, but this increase is usually temporary and often dose-related.


{{Quote|indent}}I think it aggravated the anxiety component for me. Not sure why. (After dosing with HDC){{Quote|/indent}}
{{Quote|indent}}I think it aggravated the anxiety component for me. Not sure why. (After dosing with HDC){{Quote|/indent}}
{{Quote|indent}}Around day 15 (after an initial dose of 10 NA), I had severe anxiety for 2 days straight but nothing since. [https://www.facebook.com/groups/htsupport/permalink/1820079598047987/?comment_id=1835175879871692&comment_tracking=%7B%22tn%22%3A%22R%22%7D]<!-- Stephen Pendry -->{{Quote|/indent}}


{{Quote|indent}}I had mild/moderate diffuse anxiety for about a week at ~19-20 weeks. (After a supplementary dose of '''''65''''' NA.){{Quote|/indent}}
{{Quote|indent}}I had mild/moderate diffuse anxiety for about a week at ~19-20 weeks. (After a supplementary dose of '''''65''''' NA.){{Quote|/indent}}
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{{Quote|indent}}I had a major increase in anxiety when I started whipworm (TT). But with hookworm my anxiety has improved greatly. I terminated the whipworm after 6 or 8 weeks when my reaction to them still hadn't eased, so I can't say if that feeling would have persisted or eventually passed.{{Quote|/indent}}
{{Quote|indent}}I had a major increase in anxiety when I started whipworm (TT). But with hookworm my anxiety has improved greatly. I terminated the whipworm after 6 or 8 weeks when my reaction to them still hadn't eased, so I can't say if that feeling would have persisted or eventually passed.{{Quote|/indent}}


If anxiety does arise, or worsen, after introducing helminths, this should eventually resolve along with any other symptoms that appear during the initial side effect period. Resolution is usually complete by the end of the 14 week period of immune activation following inoculation, but it has been known to persist for longer.
If anxiety does arise, or worsen, after introducing helminths, this should eventually resolve along with any other symptoms that appear during the initial side effect period. Resolution is usually complete by the end of the 14th week and, if it recurs at all following supplementary inoculations, it typically becomes gradually less troublesome over time.
 
{{Quote|indent}}I have severe anxiety, including PTSD & panic attacks etc. When I initially began treating (with NA) I would notice an increase in anxiety for several days. It would be a bit uncomfortable & high doses of D3, Benadryl, & magnesium would help. I’m honestly not sure when it stopped. Likely when the bounce stopped, so a year in? Now, the opposite occurs and I get very calm & fall asleep after treating. This usually lasts for several days.
[https://www.facebook.com/groups/htsupport/posts/4141870795868844?comment_id=4148225755233348&reply_comment_id=4149349751787615]{{Quote|/indent}}<!-- Christina Thomas -->
 
In a few rare cases, anxiety can persist for a longer period of time, leading one individual to terminate their colony.
 
{{Quote|indent}}Increase in energy and exuberance the first month, restlessness the second month, worsening anxiety/OCD third and 4th month, increased to day-long panic attacks fifth month. Directly due to hookworms as symptoms are 90% improved after 3 days of albendazole.{{Quote|/indent}}
 
== Bipolar disorder ==
 
HDC has been found to help in several cases of bipolar disorder.
 
* [[Helminthic therapy personal stories#Bipolar disorder | '''Helminthic therapy personal stories: Bipolar disorder''']]
 
And there are further reports of success with this disorder in the following paper.
* [http://www.yourwildlife.org/wp-content/uploads/2015/05/galley-proof-v2.pdf Overcoming Evolutionary Mismatch by Self-Treatment with Helminths: Current Practices and Experience]
 
== See also ==
 
* [[The helminthic therapy bounce | '''The helminthic therapy bounce''']]
 
* [[Helminthic therapy for well people#Alzheimer’s disease | '''Helminthic therapy as a potential prophylaxis for Alzheimer’s disease''']]
 
* [[Helminthic therapy for well people#Cognitive dysfunction | '''Helminthic therapy as a potential prophylaxis for Cognitive dysfunction''']]
 
* [[Helminthic therapy for well people#Dementia | '''Helminthic therapy as a potential prophylaxis for Dementia''']]
 
* [[Helminthic therapy for well people#Obsessive-compulsive disorder (OCD) | '''Helminthic therapy as a potential prophylaxis for Obsessive-compulsive disorder (OCD)''']]
 
* [[Helminthic therapy for well people#Parkinson's disease | '''Helminthic therapy as a potential prophylaxis for Parkinson's disease''']]


{{Quote|indent}}Increase in energy and exuberance the first month, restlessness the second month, worsening anxiety/OCD third and 4th month, increased to day-long panic attacks fifth month. Directly due to hookworms as symptoms are 90% improved after 3 days of abendazole.{{Quote|/indent}}
* [[Helminthic therapy for well people#Psychosis | '''Helminthic therapy as a potential prophylaxis for Psychosis''']]


=== See also ===
* [[Helminthic therapy for well people#Schizophrenia | '''Helminthic therapy as a potential prophylaxis for Schizophrenia''']]


* [[The helminthic therapy 'bounce' | '''The helminthic therapy 'bounce’''']]
* [[Helminthic therapy for well people#Tourette Syndrome | '''Helminthic therapy as a potential prophylaxis for Tourette Syndrome''']]

Latest revision as of 13:14, 27 November 2021

Home>Effects of helminthic therapy>Helminthic therapy and neuropsychiatric function


Helminths are capable of improving neuropsychiatric function, and all four species of therapeutic helminth appear to make a positive contribution to psychological wellbeing.

Quotein.gif
Socio-medical studies of humans "self-treating" with helminths as well as limited studies in animal models strongly suggest that helminth therapy may be a productive approach toward treating a range of neuropsychiatric disorders, including chronic fatigue, migraine headaches, depression and anxiety disorders. [1]

Additional supporting research includes the following paper.

Depression[edit]

Reduced depression / improved mood[edit]

HDC is mentioned a lot in this context, and, since HDC is taken regularly, usually every 2 weeks, its users can benefit from a repeated post-inoculation 'bounce’. This is a brief period of temporary symptom relief accompanied by a sudden feeling of unusual wellness, perhaps with a strong sense of calm, focus, happiness and lightheartedness.

Quotein.gif
I like how it puts me in a good mood for a day or two when I first take it.
Quotein.gif
I also experienced a significantly elevated mood that night after taking just 10 HDC, the elevated mood lasted until the end of the next day. [2]

For some people, this effect may be repeated after every dose.

Quotein.gif
... every dose of HDC's is followed by a delightful stream of energy that lasts almost a week. [3]
Quotein.gif
Within 24 hours of taking HDC I feel much calmer. That feeling lasts a few days, before it lets up a bit, but I still continue feeling calmer than usual up to 30 days after dosing, when their effects completely wear off… If I could regularly dose, say, weekly, I probably would see my anxiety completely resolved. [4]

In other cases, this effect may reduce over time.

Quotein.gif
The first day I take HDC it usually puts me in a really nice mood, especially the first time I did it. It's not exactly euphoric but I noticed it and counted on it… First time, (it lasted) 48 hours. Second time, 24 hours. Third time, 12 hours. Fourth time, 12 hours.

However, this effect on neuropsychiatric function is not unique to HDC. It is also seen with TSO, NA and TTO.

Quotein.gif
My mood was the first indicator that TSO was working. I became calmer and happier despite my physical symptoms. [5] I find TSO is the best for mood and general feeling of well being as well as increased energy. Hookworm and (human) whipworm both work as well, it just takes longer. [6]
Quotein.gif
My daughter started TSO last week and we are already seeing an improvement in her mood and energy on a low dose of 500 ova. [7]
Quotein.gif
TSO cured a mood disorder I didn't realize I had until it was gone. [8]
Quotein.gif
I would like to confirm positive effect of TSO on mood stabilization as well. Even with low dose in my case (300 ova bi-weekly). [9]

The following comment was made 6 weeks after inoculation with 25 hookworm larvae.

Quotein.gif
What is already interesting is my steady and calm mind.

For further accounts of how helminthic therapy has reduced depression, see the following.

Temporarily increased depression[edit]

Occasionally, depression may increase temporarily following initial inoculation with helminths. This is usually, but not necessarily, the result of using doses that are too high.

Quotein.gif
After first small group of NA, I became much more depressed for about 10-12 weeks, then got back to previous mood level. [10]
Quotein.gif
I have hit a patch of depression here at week 9 of my first inoculation with 3NA and I am feeling very bleak. [11]
Quotein.gif
I also feel quite depressed, will be 9 weeks for me on Tuesday. [12]
Quotein.gif
After first small group of NA, I became much more depressed for about 10-12 weeks, then got back to previous mood level. [13]

A few individuals experience increased depression after every dose of hookworms, especially if the doses contain too many larvae.

Quotein.gif
3.5 years in, I now have times where I even feel positive and optimistic, which is a huge improvement over a lifetime of clinical depression. But it’s also the first symptom to return, especially if I take a dose of NA that’s a little too much. Last dose was 7, and 3 days later I started 9 days of deep despair. I know it’s temporary, so I just hang on and get through it, but now I know 7 is too many. [14]
Quotein.gif
I experience plummeting mood following an NA inoculation. Dosing amounts are important with NA. [15]

Anxiety[edit]

Reduced anxiety[edit]

The potential for helminths to reduce anxiety can be seen in the reports in the following page section.

And in this paper. (See Table 1 in particular.)

Temporarily increased anxiety[edit]

There have been a few reports of anxiety increasing following initial inoculation with NA, TTO or HDC, but this increase is usually temporary and often dose-related.

Quotein.gif
I think it aggravated the anxiety component for me. Not sure why. (After dosing with HDC)
Quotein.gif
Around day 15 (after an initial dose of 10 NA), I had severe anxiety for 2 days straight but nothing since. [16]
Quotein.gif
I had mild/moderate diffuse anxiety for about a week at ~19-20 weeks. (After a supplementary dose of 65 NA.)
Quotein.gif
My anxiety and more-so paranoia seems to have increased significantly after hosting. Its a strange feeling but I "feel" like its the worms interacting with me somehow.
Quotein.gif
I had a major increase in anxiety when I started whipworm (TT). But with hookworm my anxiety has improved greatly. I terminated the whipworm after 6 or 8 weeks when my reaction to them still hadn't eased, so I can't say if that feeling would have persisted or eventually passed.

If anxiety does arise, or worsen, after introducing helminths, this should eventually resolve along with any other symptoms that appear during the initial side effect period. Resolution is usually complete by the end of the 14th week and, if it recurs at all following supplementary inoculations, it typically becomes gradually less troublesome over time.

Quotein.gif
I have severe anxiety, including PTSD & panic attacks etc. When I initially began treating (with NA) I would notice an increase in anxiety for several days. It would be a bit uncomfortable & high doses of D3, Benadryl, & magnesium would help. I’m honestly not sure when it stopped. Likely when the bounce stopped, so a year in? Now, the opposite occurs and I get very calm & fall asleep after treating. This usually lasts for several days. [17]

In a few rare cases, anxiety can persist for a longer period of time, leading one individual to terminate their colony.

Quotein.gif
Increase in energy and exuberance the first month, restlessness the second month, worsening anxiety/OCD third and 4th month, increased to day-long panic attacks fifth month. Directly due to hookworms as symptoms are 90% improved after 3 days of albendazole.

Bipolar disorder[edit]

HDC has been found to help in several cases of bipolar disorder.

And there are further reports of success with this disorder in the following paper.

See also[edit]