Difference between revisions of "Helminthic therapy and infectious diseases"

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(Helminthic therapy and herpes: Added a quote and comment.)
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Helminthic therapy should bring about a reduction in outbreaks of herpes once the worms have been hosted for a few months.  
 
Helminthic therapy should bring about a reduction in outbreaks of herpes once the worms have been hosted for a few months.  
  
{{Quote|indent}}I used to get cold sores throughout my adult life frequently and easily ~ the slightest trigger of sunburn, stress, colds, etc. would cause them to appear. Sometimes one would be just healing when another would start. Such a drag! Since HT the incidence of coldsores/HSV outbreaks has drastically dropped to almost none. (Edited from two posts: [https://www.facebook.com/groups/htsupport/permalink/920184614704161/?comment_id=920189144703708&comment_tracking=%7B%22tn%22%3A%22R%22%7D] [https://www.facebook.com/groups/htsupport/permalink/782288488493775/?comment_id=1417916654930952&comment_tracking=%7B%22tn%22%3A%22R%22%7D]){{Quote|/indent}}
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{{Quote|indent}}I used to get cold sores throughout my adult life frequently and easily ~ the slightest trigger of sunburn, stress, colds, etc. would cause them to appear. Sometimes one would be just healing when another would start. Such a drag! Since HT the incidence of coldsores/HSV outbreaks has drastically dropped to almost none. My HSV1 only appeared once in 3.5 years after a brutal sunburn. (Edited from three posts: [https://www.facebook.com/groups/htsupport/permalink/920184614704161/?comment_id=920189144703708&comment_tracking=%7B%22tn%22%3A%22R%22%7D] [https://www.facebook.com/groups/htsupport/permalink/782288488493775/?comment_id=1417916654930952&comment_tracking=%7B%22tn%22%3A%22R%22%7D] [https://www.facebook.com/groups/htsupport/permalink/1667358526653429/?comment_id=1667450016644280&comment_tracking=%7B%22tn%22%3A%22R%22%7D]){{Quote|/indent}}
  
 
{{Quote|indent}}The following year, I have had far less frequent cold sores than I have ever had in my life which i attribute to increased overall health due to the helminths. [https://www.facebook.com/groups/htsupport/permalink/1482913471764603/?comment_id=1483140678408549&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote|/indent}}
 
{{Quote|indent}}The following year, I have had far less frequent cold sores than I have ever had in my life which i attribute to increased overall health due to the helminths. [https://www.facebook.com/groups/htsupport/permalink/1482913471764603/?comment_id=1483140678408549&comment_tracking=%7B%22tn%22%3A%22R%22%7D]{{Quote|/indent}}

Revision as of 15:52, 24 May 2018

Home>Effects of helminthic therapy>Helminthic therapy and infectious diseases

Helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. and susceptibility to infectious diseases

People enquiring about helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. are often concerned that the treatment might reduce their ability to fight common infections, but the effect that helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] have on the immune system is complex and not simply a matter of reducing an excessive response. What helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] do is more a case of subtle modulation, i.e., balancing or quieting rather than suppression, of immunity, and they achieve this by deploying an orchestra of molecules with the intension of keeping themselves and their host alive and well for as long as possible. See The effects of helminths on the immune system.

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Some investigators worry that helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] could weaken patients' immune systems and leave them more vulnerable to some types of infectious diseases, even under careful medical supervision. But as long as society maintains its current modern hygienic standards, I consider this risk negligible. Given the lack of side effects from helminth therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy., morbidity from immune-mediated diseases, and the toxicities of modern therapies for them, almost certainly exceed the risk from helminthic exposure. [1]

In fact, we can be rather confident in the ability of helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] to modulate the immune system without immunocompromising the host, [2] a view supported by William Parker, whose team at Duke University have found enhanced rather than suppressed immune function in animals with increased biodiversity.

Parker says that, far from making the immune system lazy or less effective, helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] actually make it smarter.

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People who host helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] can still mount an inflammatory attack on pathogens, but they don't set off self-destructive immune bombs against harmless substances or their own cells.

There is also evidence from elsewhere that intestinal parasitesAn organism that lives in or on another organism (its host) and benefits at the host’s expense. (The organisms used in helminthic therapy are, strictly speaking, not parasites, but mutualists, because they have a mutually beneficial symbiotic relationship with their hosts.) may help the body ward off some infections.

The experience of helminth self-treaters

There are reports of both less, and more, infections while hosting worms, but the majority of self-treaters appear to experience a reduced incidence of infection.

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Don't think I've caught a single cold since my infection with hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. a couple of years ago. [3]
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My immunity seems better with HWhookworm, usually referring to the human hookworm, Necator americanus. I have an immune deficiency that makes me more susceptible to upper respiratory infections. Since starting HWhookworm, usually referring to the human hookworm, Necator americanus I have successfully fought of infection which is VERY unusual for me. My husband had a cold. Normally that is a disaster for me as a cold in someone else almost always leads to chest infection and bronchitis in me. For the first time in more years than I remember I sniffled for a day and fought it off. (Edited from two posts.) [4] [5]
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Anecdotally, I haven't had a single cold or flu since inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] last March.
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It will be 2 years (next month) with helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths]. I have around 135 (NAthe human hookworm, Necator americanus)… I have not had flu or a cold for the last 2 winters even though whole family had severe chest and throat infections. Prior to the worms I would get flu every winter. First holiday last August to Kenya where I did not get ill. [6]
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Have been hosting for over 3 years as a reservoir donor. No colds in this time.
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I have the flu. I know because my son just tested positive with the nasal swab test. My immune response has been very different from years past, I've always coughed like crazy which ended up as bronchitis, and I've spiked a fever. But this time I have very little coughing and only a low grade fever. 24 hrs later and I'm almost completely over it. I attribute this to having hosted human hookwormsA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. for the past nine months. My body is better at handling infection now. [7]
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I used to have a cold every 6-8 weeks. My whole life. Since getting NAthe human hookworm, Necator americanus almost 2 years ago I've only been ill once. [8]
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I don't get sinus infections that last for six months any more. I don't get colds that turn into sinus infections. [9]

In some cases, the normalisation of immune function by helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] can result in people who previously rarely got infections beginning to get them more frequently.

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I got my first cold in years 6 weeks after my first inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation]. [10]
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Since I inoculated over 3 years ago, I get sick way way more often. I have Crohn's diseaseAlso known as regional enteritis, this is an inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms. It primarily causes abdominal pain, diarrhea (which may be bloody if inflammation is severe), vomiting or weight loss, but may also cause complications outside the gastrointestinal tract such as skin rashes, arthritis, inflammation of the eye, tiredness and lack of concentration. and before my worms I was almost never sick and I was usually the lone person in my house who stayed "healthy" while illnesses ran through everyone else. One of the theories about crohns being due to an overactive immune system seems to be true for me. The worms have dramatically reduced my crohns symptoms but in exchange I catch just about any illness my young kids bring home from school. It's completely worth it, though, as colds, flus, strep, etc on occasion are nothing compared to the pain of crohns! [11]
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Prior to HThelminthic therapy I didn't get many colds. Now I get colds and flu bugs more often. I think when my immune system was over reactive it killed everything quickly, including attacking my gut. Now that it's less active and colds and flus take hold more often. [12]
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Since inoculating less than six months ago I've had my first sinus infection in 43 years, my first lung infection and my first skin infection. None were too serious - but it seems unlikely to be a coincidence. I've always been the person you couldn't give a bacterial infection to if you tried. Having said that, two pesky warts I've had for over a decade have disappeared. I'd say something is shifting! I should point out that I'll take some mild bacterial infections over 4 autoimmune diseases any day. [13]
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I never had flu or cold for the last 20 years or what I can remember. Not even once a sneeze or running nose. But after the helminth therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy., I have a flu or cold episode at least twice a year. [14]

How infections impact on the benefits of helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy.

When someone who is hosting helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] gets an infection, such as a cold or the flu, this can cause a brief return of symptoms of whatever disease they are treating.

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I had a flu 10 days ago and had a return of crohn’s symptoms. [15]
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… any time I get a cold/flu it exacerbates all my allergy-related symptoms by revving up my immune system (especially congestion/headaches, eczema & muscle/joint pain). [16]
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I am 7½ months into hwhookworm, usually referring to the human hookworm, Necator americanus therapy to cope with rhinitis… Last week I caught a minor cold from my kids and have had the worst allergy attack lasting all week. [17]
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I have noticed that my old symptoms (systemic reaction to food) that are now much better, flare whenever I get a cold… It does appear to happen each time I get a virus so far…[18]

This return of disease symptoms does not occur because the infection has a direct effect on the worms themselves, which may continue to secrete their immune modulating molecules while the infection is active. However, since the effect of these excretory/secretory products is subtle, this may be overwhelmed by the increased activity of the immune system, resulting in the temporary reappearance of symptoms.

If any substance is taken which enhances the immune response, this may also increase the symptoms of autoimmune diseases, making it appear that the substance itself has adversely affected the worms. For example, this can occur with the use of elderberry. [19] [20] (Also see the comments here and here.)

When the immune system settles back to it’s normal level of activity after dealing with an infection and after the use of any immune enhancing substances has ceased, the impact of the worms’ subtle immune modulation will once again become evident, and disease symptoms will gradually subside.

Normal immune balance may be restored within 2-3 weeks after a cold or the flu but, in the case of the latter, it may take a while after the viral infection has been cleared, especially if a secondary bacterial infection develops in its wake.

Helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. and chronic infections

Some people with chronic infections have noticed an increase in the number and severity of outbreaks after introducing helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths], especially those people who were already suffering frequent outbreaks prior to starting helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy.. Infections such as tuberculosis (TB), Lyme disease, herpes, hepatitis, HIV and CMV, etc., may surge during the early response phase following helminth introduction, because this alters the immune reaction and may reduce the body's ability to suppress active infection. [21] For example, some, but not all, subjects with Herpes may notice more frequent outbreaks after commencing helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy., and helminth providers may decline to supply someone with a more serous chronic and incurable infection, such as those who are HIV positive.

Anyone with an active chronic, or incurable, infection who does go ahead with helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. would be advised to consult their physician prior to treatment, and to take steps - for instance increasing prophylactic or suppression therapy - to ameliorate the immunomodulatory effect in the early stages of helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy..

See also:

Helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. and viral infections

The precise interactions that occur between helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] and viruses are still poorly understood, but it is known that some latent viral infections, such as herpes and tuberculosis, can be reactivated temporarily following infection with a parasiteAn organism that lives in or on another organism (its host) and benefits at the host’s expense. (The organisms used in helminthic therapy are, strictly speaking, not parasites, but mutualists, because they have a mutually beneficial symbiotic relationship with their hosts.) such as the one that causes malaria.

One study has revealed how signals from the immune system that help repel a common parasiteAn organism that lives in or on another organism (its host) and benefits at the host’s expense. (The organisms used in helminthic therapy are, strictly speaking, not parasites, but mutualists, because they have a mutually beneficial symbiotic relationship with their hosts.) can inadvertently cause the reactivation of a dormant herpes virus. [22]

However, the temporary reactivation of dormant viral infections does not happen in all cases and there may even be a reduction in viral activity following inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation], with amelioration of pathology without any increase in susceptibility to, or persistence of, the viral infection. [23]

The rate of progression of HIV disease is no different in populations living in helminth endemic parts of the world compared with the western world, where helminth infections are now almost non-existent. By balancing interactions between inflammatory and regulatory responses, helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] may produce an effect that is at least neutral, and perhaps even protective, for example by reducing the progression of HIV. [24]

Helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. and herpes

As with other viral infections, herpes may be worsened or reactivated temporarily following the introduction of helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths]. [25]

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I get cold sores and noticed a small increase shortly after inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation]. [26]

Any exacerbation following inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] should only last up to approximately 6 months, and any doses added while the herpes flare is still active may cause an increase in symptoms, especially within the first 3 or 4 months, i.e., before the first cohort of worms is able to fully exert its suppressive effect on the immune response to itself.

Helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. should bring about a reduction in outbreaks of herpes once the worms have been hosted for a few months.

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I used to get cold sores throughout my adult life frequently and easily ~ the slightest trigger of sunburn, stress, colds, etc. would cause them to appear. Sometimes one would be just healing when another would start. Such a drag! Since HThelminthic therapy the incidence of coldsores/HSV outbreaks has drastically dropped to almost none. My HSV1 only appeared once in 3.5 years after a brutal sunburn. (Edited from three posts: [27] [28] [29])
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The following year, I have had far less frequent cold sores than I have ever had in my life which i attribute to increased overall health due to the helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths]. [30]
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Since inoculating, I have not had any cold sores… I'd say my immune system is working well that way! [31]
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My cold sores have reduced since taking HWshookworm, usually referring to the human hookworm, Necator americanus over a period of 1.5 years. [32]

Occasionally, herpes may improve in the first few weeks following inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation].

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I'm three weeks in and I haven't had a single cold sore which is really rare for me. [33] Week 6 update… I still have not had another cold sore. This is considering I used to get them once to twice a week!! [34]

Supplementary doses may cause a temporary flare of herpes, especially following overly large doses.

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I get cold sores and they do get worse (after inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation]) but antivirals pretty much fix it. Plus no outbreak is as bad as when you first get cold sores. [35]

There is also a possibility of a large hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. dose - even a supplementary one - triggering shingles.

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I can't prove this but my shingles began following this bad reaction to 25 hookwormsA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin.. [36]

Herpes appears to be treatable using high doses of vitamin C, a course of which could be taken prior to, or concurrent with helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy.. [37] [38]

Helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. and tuberculosis (TB)

HelminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] may enhance TB infection, whether newly acquired or reactivated. [39] and they may reduce the effect of any anti-TB therapy. [40] However, Infection with the human whipwormA helminth with a tapering whiplike body that lives in the colon. In helminthic therapy, the microscopic eggs of either the human Trichuris trichiura (TTO) or pig Trichuris suis (TSO) are taken in a drink., Trichuris trichiuraThe human whipworm used in helminthic therapy and taken periodically as microscopic eggs (TTO) in a drink., may provide protection against acquiring a TB infection. [41]

In order to combat TB, a certain degree of immune vigilance is required, but a hyper-vigilant immune system will increase the risk of autoimmune disease. The effects of helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. in TB must be seen in relation to this dynamic.

Here is more of the relevant research.

See also