Difference between revisions of "Helminthic therapy and fecal microbiota transplant (FMT)"

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* [[Crohns and colitis patient bounces back to health with hookworms and fecal transplants | '''Crohn's and colitis patient bounces back to health with hookworms and fecal transplants''']]
* [[Crohns and colitis patient bounces back to health with hookworms and fecal transplants | '''Crohn's and colitis patient bounces back to health with hookworms and fecal transplants''']]
* [https://pubmed.ncbi.nlm.nih.gov/34517928/ Cooperation between host immunity and the gut bacteria is essential for helminth-evoked suppression of colitis] -- [https://www.researchgate.net/publication/354561896 Full text]


== Further information ==
== Further information ==

Latest revision as of 20:57, 14 September 2021


HT and FMT can be complementary[edit]

A healthy microbiome and a few probiotic helminths can complement each other, so the combination of FMT with helminthic therapy may be more effective than either one used alone.

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Our findings show that murine intestinal helminth infection not only alters the intestinal bacterial communities but that intestinal bacteria contribute to the ability of helminth infection to attenuate allergic airway inflammation. [1]

Reports from those who have used both therapies confirm that helminthic therapy (HT) and faecal microbiota transplant (FMT) are a very effective combination.

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I have Hashimoto's and some related symptoms: food intolerances, migraines, fatigue, poor endurance. Many of my symptoms are under control thanks to diet and FMT. Using those modes of treatment my anti thyroid antibodies decreased to about 80-100, but whatever I did I could not decrease them further. Well, now, 4-5 months into TSO (and I’m probably taking too small dose of 700 ova) my antibodies test results came back at 58. It is not a huge improvement, but it is an improvement and they would not budge any other way, so I am very happy. I also feel better and stronger - subjectively. [2]

It may be best to start HT and FMT separately[edit]

If intending to do both therapies, it can help to start them separately so that it will be easier to determine which is producing any benefits or side effects that appear.

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As someone who has done FMTs and just started on worms I suggest doing one thing at a time, at first anyway. This is so you can assess the benefits and side effects of each treatment. If you do both at once and some symptoms improve while you also get side effects you won't be able to tell the cause. [3]

Which to do first: HT or FMT?[edit]

A few people recommend starting with FMT.

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I did FMT first and I'm glad I did. my NA are part of the solution but could not have fixed my microbiota deficits. [4]
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As a first step, I suggest doing one or a few FMTs in order to knock out any pathogenic bacteria you may have in your gut. That may also kick start rebuilding your gut flora. Then try some helminths. Give them several months to settle in and reduce inflammation. Then assess your situation and make an educated guess as to whether more FMTs and/or worms may help further. [5]

While the majority favour doing helminthic therapy first.

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Helminths reduce inflammation and secrete compounds that favour beneficial bacteria. Exactly what you need (besides a good diet) for the new bacteria to stick [6]
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I think doing the helminths first would increase the chances of having a successful FMT. I did a series of FMTs a few years ago and had very little change in my condition, and I think I was too inflamed for it to take. [7]
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I had FMT for IBS/food intolerances 1½ years ago and I have to say it was no golden bullet… I have just started Helminthic therapy but looking back I would do the Helminthic therapy first as it is cheaper and depending on the root causes it may also be more effective… [8]
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I would definitely recommend commencing HT before FMT. I did FMT in August and inoculated with 5NA in September. I have been in a notable flare (Hashimoto's and Sjogren’s) since undergoing FMT. So far, I'm tolerating the NA well… (Link expired)
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My argument for doing worms before FMT is that the side effects of the worms (diarrhea) might erase the newly acquired flora. [9]
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I would second the recommendation to try HT first. (Link expired)
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I did FMT (5 months ago) -- just prior to HT -- and I'm still flaring from the treatment... I wish I had commenced HT first. [10]

And the following comment is from a paediatrician.

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… if somebody came in to me with recalcitrant Clostridium and nothing had worked… I would do FMT first. But if a child’s coming in with autoimmune disease or autism and that’s what they’re considering, I would do (HT) hands down for months before I would even consider FMT. [11]

FMTs from a helminth-hosting donor may have an edge[edit]

It is possible that a fecal transplant from a healthy donor who is hosting helminths might have additional therapeutic potential as a result of the helminth components it will contain.

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The immuno-modulatory capacity of helminth infection could be transferred through fecal transplantation and correlated with an increased availability of microbial-derived short chain fatty acids (SCFAs). [12]

See also[edit]

Further information[edit]

FMT websites

  • FMT notes by Maximilian Kohler
  • The Power of Poop This once excellent site is no longer being cared for by anyone with a genuine interest in FMT. The site was "obtained" by an online payday loans company that is using it merely as a vehicle for advertising its services via links sprinkled unobtrusively across the site's pages.

FMT support groups

  • FMT & Bacteriotherapy Discussion This is a secret Facebook group that was once administered by the owner of the Power of Poop website (see FMT websites, above), so ask in the Helminthic Therapy Support group if any of your Facebook friends there are also members of this group and can add you to it.