Difference between revisions of "Helminthic therapy and cancer"

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(Helminths may provide protection against cancer)
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==== Some helminths can cause cancer, but not NA, TT, TS or HD ====
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=== Some helminths can cause cancer, but not NA, TT, TS or HD ===
  
 
Some helminths have been identified as being carcinogenic, but these don’t include any of the helminths used for therapeutic purposes.
 
Some helminths have been identified as being carcinogenic, but these don’t include any of the helminths used for therapeutic purposes.
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It isn’t in a worm's interests to make its host more susceptible to anything that might kill it, as is explained in this support group [https://www.facebook.com/groups/htsupport/permalink/862869457102344/?comment_id=862871853768771&offset=0&total_comments=1&comment_tracking=%7B%22tn%22%3A%22R%22%7D&__mref=message_bubble post].
 
It isn’t in a worm's interests to make its host more susceptible to anything that might kill it, as is explained in this support group [https://www.facebook.com/groups/htsupport/permalink/862869457102344/?comment_id=862871853768771&offset=0&total_comments=1&comment_tracking=%7B%22tn%22%3A%22R%22%7D&__mref=message_bubble post].
  
==== Helminths may provide protection against cancer ====
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=== Cancer has been linked to inflammation, and helminths control inflammation ===
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* [http://www.hopkinsmedicine.org/news/media/releases/chronic_inflammation_linked_to_high_grade_prostate_cancer Chronic Inflammation Linked to High-Grade Prostate Cancer]
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* [http://www.sciencedaily.com/releases/2015/04/150430113205.htm Pre-existing inflammation (from allergic reactions) may promote the spread of cancer]
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=== Helminths may protect against cancer ===
  
 
Helminths may offer protection against at least some forms of cancer rather than increase our susceptibility to it.
 
Helminths may offer protection against at least some forms of cancer rather than increase our susceptibility to it.
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The apoptotic abilities of some worm-derived molecules make them potential candidates for anti-cancer drugs.
 
The apoptotic abilities of some worm-derived molecules make them potential candidates for anti-cancer drugs.
  
==== Helminthic may be able to treat cancer ====
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=== Helminths and their products may potentially treat cancer ===
  
 
The apoptotic abilities of some worm-derived molecules make them potential candidates for anti-cancer drugs.  
 
The apoptotic abilities of some worm-derived molecules make them potential candidates for anti-cancer drugs.  
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* [https://www.ncbi.nlm.nih.gov/pubmed/28659212 Helminth-induced apoptosis: a silent strategy for immunosuppression.]
 
* [https://www.ncbi.nlm.nih.gov/pubmed/28659212 Helminth-induced apoptosis: a silent strategy for immunosuppression.]
  
==== Cancer has been linked to inflammation, and helminths control inflammation ====
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=== Infection with other microorganisms may also help to reduce cancer risk ===
 
 
* [http://www.hopkinsmedicine.org/news/media/releases/chronic_inflammation_linked_to_high_grade_prostate_cancer Chronic Inflammation Linked to High-Grade Prostate Cancer]
 
 
 
* [http://www.sciencedaily.com/releases/2015/04/150430113205.htm Pre-existing inflammation (from allergic reactions) may promote the spread of cancer]
 
 
 
==== Infection with other microorganisms may also help to reduce cancer risk ====
 
  
 
{{Quote|indent}}Researchers found that enhanced biodiversity (of bacteria and worms) was associated with better immune responsiveness. Specifically, they found better responses to vaccination, better T-cell responses, and much higher levels of "natural" antibodies, which have been shown to be important in fighting cancer. [http://www.sciencedaily.com/releases/2015/04/150408145242.htm] {{Quote|/indent}}
 
{{Quote|indent}}Researchers found that enhanced biodiversity (of bacteria and worms) was associated with better immune responsiveness. Specifically, they found better responses to vaccination, better T-cell responses, and much higher levels of "natural" antibodies, which have been shown to be important in fighting cancer. [http://www.sciencedaily.com/releases/2015/04/150408145242.htm] {{Quote|/indent}}
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{{Quote|indent}}…attenuated responses to tumor antigens as a result of biome depletion might underlie, at least in part, the proposed connection between increased rates of cancer and biome depletion. Further, decreased levels of “natural” IgG and IgM observed in biome depleted (laboratory) environments could exacerbate the problem, since the natural antibody repertoire is involved in tumor surveillance. In this manner, decreased tumor surveillance in biome depleted environments could promote cancer progression and operate synergistically with biome depletion-associated inflammation, a potential initiator and promoter of carcinogenesis. [http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0120255] {{Quote|/indent}}
 
{{Quote|indent}}…attenuated responses to tumor antigens as a result of biome depletion might underlie, at least in part, the proposed connection between increased rates of cancer and biome depletion. Further, decreased levels of “natural” IgG and IgM observed in biome depleted (laboratory) environments could exacerbate the problem, since the natural antibody repertoire is involved in tumor surveillance. In this manner, decreased tumor surveillance in biome depleted environments could promote cancer progression and operate synergistically with biome depletion-associated inflammation, a potential initiator and promoter of carcinogenesis. [http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0120255] {{Quote|/indent}}
  
==== When a helminth, itself, gets cancer ====
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=== When a helminth, itself, gets cancer ===
  
 
A case in which a man died after a tapeworm inside him developed cancer involved a helminth that is not used in therapy.
 
A case in which a man died after a tapeworm inside him developed cancer involved a helminth that is not used in therapy.

Revision as of 00:03, 2 July 2017

Some helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] can cause cancer, but not NAthe human hookworm, Necator americanus, TTthe human whipworm, Trichuris trichiura, TSthe porcine (pig) whipworm, Trichuris suis or HDHymenolepis diminuta, a murine (rat) tapeworm.

Some helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] have been identified as being carcinogenic, but these don’t include any of the helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] used for therapeutic purposes.

It isn’t in a worm's interests to make its host more susceptible to anything that might kill it, as is explained in this support group post.

Cancer has been linked to inflammation, and helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] control inflammation

HelminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] may protect against cancer

HelminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] may offer protection against at least some forms of cancer rather than increase our susceptibility to it.

HelminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] may be able to elicit anti-tumor immune responses that can lead to protection from tumorigenesis, or even to cancer regression.

Helminth infection may reduce the risk of colitis-associated tumour formation.

Helminth infection may alter inflammatory responses to H. pylori and thus affect the progression of gastritis to gastric atrophy, dysplasia, and cancer.

The apoptotic abilities of some worm-derived molecules make them potential candidates for anti-cancer drugs.

HelminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] and their products may potentially treat cancer

The apoptotic abilities of some worm-derived molecules make them potential candidates for anti-cancer drugs.

Infection with other microorganisms may also help to reduce cancer risk

Quotein.gif
Researchers found that enhanced biodiversity (of bacteria and worms) was associated with better immune responsiveness. Specifically, they found better responses to vaccination, better T-cell responses, and much higher levels of "natural" antibodies, which have been shown to be important in fighting cancer. [1]

BCG vaccination in infancy confers a survival advantage for melanoma patients, and vaccination of adults against yellow fever may have a similar effect.

Infection with the feline parasiteAn organism that lives in or on another organism (its host) and benefits at the host’s expense. (The organisms used in helminthic therapy are, strictly speaking, not parasites, but mutualists, because they have a mutually beneficial symbiotic relationship with their hosts.), Toxoplasma gondii, stimulates the body to produce natural killer cells and cytotoxic T cells, which wage war on cancer cells.

Rather than the presence of infectious microorganisms increasing cancer risk, a lack of them may be the greater problem.

Quotein.gif
…attenuated responses to tumor antigens as a result of biome depletion might underlie, at least in part, the proposed connection between increased rates of cancer and biome depletion. Further, decreased levels of “natural” IgG and IgM observed in biome depleted (laboratory) environments could exacerbate the problem, since the natural antibody repertoire is involved in tumor surveillance. In this manner, decreased tumor surveillance in biome depleted environments could promote cancer progression and operate synergistically with biome depletion-associated inflammation, a potential initiator and promoter of carcinogenesis. [2]

When a helminthAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths], itself, gets cancer

A case in which a man died after a tapewormA helminth with a flat, ribbon-like, segmented body. Only the murine (rat) tapeworm, Hymenolepis diminuta, is used in helminthic therapy and this generally does not reach adulthood in humans so requires regular dosing of HDC. inside him developed cancer involved a helminth that is not used in therapy.

For more discussion about this case, see this support group thread.