William Parker and helminthic therapy
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Helminthic Therapy Wiki: documenting the science, management, experience and results of helminth replacement therapy.
Prof William Parker is a biophysicist who, until his retirement from Duke University in 2021, was director of one of the world's largest transplant research laboratories.
This page is currently under construction. The list of publications, below, is complete, but please call back at a later date to read details about Parker and his work.
Publications relating to helminthic therapy[edit]
The following publications emanated from Parker and his colleagues at the Immune Dysfunction and Evolutionary Mismatch Laboratory at Duke University and their collaborators at other centres.
- 2021 Dec Evolutionary medicine helps explain pandemic dynamics: Predictions regarding clinical impact of COVID-19 borne out (Also see Helminthic therapy and COVID-19.)
- 2021 Nov Socio-medical studies of individuals self-treating with helminths provide insight into clinical trial design for assessing helminth therapy (PDF) This paper highlighted current limits in scientific understanding of the biology of both helminths and their hosts, revealed how this has contributed to the failure of many recent clinical trials of helminthic therapy, and suggested that the community of self-treaters may represent the primary “lab” for research into this therapy.
- 2021 Feb Between a hygiene rock and a hygienic hard place: Avoiding SARS-CoV-2 while needing environmental exposures for immunity -- Full text | PDF (Also see Helminthic therapy and COVID-19.)
- 2018 Production of Hymenolepis diminuta in the Laboratory: An Old Research Tool with New Clinical Applications | PDF]
- 2017 Nov Evolution of the hygiene hypothesis into biota alteration theory: What are the paradigms and where are the clinical applications? | PDF
- 2017 Oct Production and Use of Hymenolepis diminuta Cysticercoids as Anti-Inflammatory Therapeutics -- Full text
- 2017 Jul Not infection with parasitic worms, but rather colonization with therapeutic helminths | PDF
- 2016 May Practices and outcomes of self-treatment with helminths based on physicians' observations | PDF This was the first study to examine, through the eyes of their physicians, the practices and experiences of those who are self-treating with helminths.
- 2015 May Approaches to studying and manipulating the enteric microbiome to improve autism symptoms -- Full text | PDF
- 2015 May Microbiome Research in Autism Spectrum Disorders (Video - Helminths mentioned from 34 minutes)
- 2015 Apr Overcoming Evolutionary Mismatch by Self-Treatment with Helminths: Current Practices and Experience (PDF) This was the first study to investigate the methods and outcomes reported by individuals self-treating with helminths.
- 2015 Apr Increased Biodiversity in the Environment Improves the Humoral Response of Rats -- Full text | PDF (Also reported by Science Daily. [1])
- 2015 Jan A model for the induction of autism in the ecosystem of the human body: the anatomy of a modern pandemic? -- Full text | PDF
- 2014 Aug The "hygiene hypothesis" for allergic disease is a misnomer (No abstract)
- 2013 Jan Evolutionary biology and anthropology suggest biome reconstitution as a necessary approach toward dealing with immune disorders -- Full text | PDF This paper explains how the modern pandemics of autoimmune, inflammatory and allergic disease are due to the loss of species, especially helminths, from the human ecosystem.
- 2012 Jun Is autism a member of a family of diseases resulting from genetic/cultural mismatches? Implications for treatment and prevention -- Full text | PDF
- 2012 Jul A prescription for clinical immunology: the pills are available and ready for testing. A review -- Full text
Helminthic Therapy Wiki: documenting the science, management, experience and results of helminth replacement therapy.