Difference between revisions of "Hookworm dosing and response"

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'''Socio-medical research confirms established best dosing practice'''
'''Socio-medical research confirms established best dosing practice'''


Socio-medical research published in 2020 [https://helminthictherapywiki.org/wiki/images/9/94/Socio-medical_studies_of_individuals_self-treating_with_helminths_suggest_that_most_clinical_trials_assessing_helminth_therapy_may_be_designed_to_fail.pdf] confirmed what had been learned by self-treaters over the previous 8 years - that there is such wide variation between individuals in their ability to tolerate helminths, and in their therapeutic response to them, that the use of individualised dosing is essential. By 2020, this was already appreciated by the majority of helminth suppliers and those physicians who provide information to self-treaters, and the use of an initial dose-finding approach was being widely recommended and practised in preference to attempting therapy with a standard dose applied to all individuals.  
Socio-medical research published in 2020 [https://helminthictherapywiki.org/wiki/images/9/94/Socio-medical_studies_of_individuals_self-treating_with_helminths_suggest_that_most_clinical_trials_assessing_helminth_therapy_may_be_designed_to_fail.pdf] confirmed what had been learned by self-treaters over the previous 8 years, viz., that there is such wide variation between individuals in their ability to tolerate helminths, as well as in their therapeutic response to them, that the use of individualised dosing is essential. By 2020, this was already appreciated by the majority of helminth suppliers and those physicians who provide information to self-treaters, and the use of an initial dose-finding approach was being widely recommended and practised in preference to attempting therapy with a standard dose applied to all individuals.  


As is explained in detail on the rest of this page, the dose-finding approach used initially in hookworm-naive individuals entails starting with a dose of 3-5 NA larvae and then slowly working up to higher doses until either symptoms are relieved or adverse side effects indicate a need to reduce dosage. Failure to start with low exposure levels of NA was described by one of the physicians interviewed by the researchers as being irresponsible and fraught with problems.  
As is explained in detail on the rest of this page, the dose-finding approach used initially in hookworm-naive individuals entails starting with a dose of 3-5 NA larvae and then gradually working up to higher doses until either symptoms are relieved or adverse side effects indicate a need to reduce dosage. Failure to start with low exposure levels of NA was described by one of the physicians interviewed by the researchers as being irresponsible and fraught with problems.  
   
   
If future clinical trials are to effectively test the potential of helminth therapy, they must address the challenge of implementing dose-finding schemes in their subject cohorts. And, if self-treaters are to be guided towards reaping the greatest benefits from this therapy without incurring undue side effects, all helminth providers and advising physicians must also adopt the dose-finding approach.
If future clinical trials are to effectively test the potential of helminth therapy, they must address the challenge of implementing dose-finding schemes in their subject cohorts. And, if self-treaters are to be guided towards reaping the greatest benefits from this therapy without incurring undue side effects, all helminth providers and advising physicians must also adopt the dose-finding approach.
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{{Quote|indent}}I do 5 NA every 7 weeks. If I do it more often, I feel sick and flared up. If I space it out more, my autoimmune symptoms return. I listen to my body and this is what it needs at this point. I journal my symptoms so I’m able to see the patterns. [https://www.facebook.com/groups/htsupport/permalink/3271274592928473?comment_id=3272967132759219]{{Quote|/indent}}
{{Quote|indent}}I do 5 NA every 7 weeks. If I do it more often, I feel sick and flared up. If I space it out more, my autoimmune symptoms return. I listen to my body and this is what it needs at this point. I journal my symptoms so I’m able to see the patterns. [https://www.facebook.com/groups/htsupport/permalink/3271274592928473?comment_id=3272967132759219]{{Quote|/indent}}
'''1-2 weeks'''
'''1-2 weeks'''
Several people who began to increase the frequency of doses, while reducing the number of larvae in each dose, have continued this process until they were dosing every one or two weeks.
Several people who began to increase the frequency of doses, while reducing the number of larvae in each dose, have continued this process until they were dosing every one or two weeks.
Someone who is treating ankylosing spondylitis went first from dosing quarterly to adding 10-15 NA every other month. [https://www.facebook.com/groups/htsupport/permalink/1150956801626940/?comment_id=1152010544854899&comment_tracking=%7B%22tn%22:%22R1%22%7D] Then, finally, he changed to adding 6 NA every two weeks. [https://www.facebook.com/groups/htsupport/permalink/2033965626659382/?comment_id=2034247119964566&reply_comment_id=2034346819954596&comment_tracking=%7B%22tn%22%3A%22R%22%7D]
Someone who is treating ankylosing spondylitis went first from dosing quarterly to adding 10-15 NA every other month. [https://www.facebook.com/groups/htsupport/permalink/1150956801626940/?comment_id=1152010544854899&comment_tracking=%7B%22tn%22:%22R1%22%7D] Then, finally, he changed to adding 6 NA every two weeks. [https://www.facebook.com/groups/htsupport/permalink/2033965626659382/?comment_id=2034247119964566&reply_comment_id=2034346819954596&comment_tracking=%7B%22tn%22%3A%22R%22%7D]
Another self-treater, who had begun dosing with 30 NA every 6 months, changed to 5 every month.


{{Quote|indent}}I've found that this new schedule is much better at keeping my sinuses clear. I'm beginning to think that the number of larva is much less important than the frequency of inoculation. [https://www.facebook.com/groups/htsupport/permalink/1258218517567434/]{{Quote|/indent}}  
{{Quote|indent}}I've found that this new schedule is much better at keeping my sinuses clear. I'm beginning to think that the number of larva is much less important than the frequency of inoculation. [https://www.facebook.com/groups/htsupport/permalink/1258218517567434/]{{Quote|/indent}}  

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