Helminthic therapy and organ transplantation

From Helminthic Therapy wiki
Jump to: navigation, search

Home>Effects of helminthic therapy>Helminthic therapy and organ transplantation

Pathogenic helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] may present a risk for organ transplant patients, and three possible scenarios are mentioned in the literature.

  • a helminth infection acquired from the donated organ,
  • a latent helminth infection reactivated as a result of post-transplantation immunosuppression,
  • a new helminth infection acquired during the immunosuppressed post-transplantation period.

However, it appears unlikely that hosting any of the currently available therapeutic helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] will present a threat to a transplant recipient.

Quotein.gif
… regardless of whether the transplanted organ was the point of entry of the helminth into the recipient or the helminthiasis was a consequence of the subsequent immunosuppression, only those helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] capable of multiplying in human beings—thus increasing their number—and able to invade various organs and tissues are, in my opinion, relevant and deserve special attention. Therefore, in this sense, the only helminthiasis that constitutes a serious threat to transplant recipients is strongyloidiasis. The only other helminth capable of multiplying in people is the tapewormA helminth with a flat, ribbon-like, segmented body. Only the murine (rat) tapeworm, Hymenolepis diminuta, is used in helminthic therapy and this generally does not reach adulthood in humans so requires regular dosing of HDC. Hymenolepis nanaA species of murine (rat) tapeworm closely related to Hymenolepis diminuta but not suitable for use in therapy because it can reproduce within a host and spread person-to-person. Also known as Dwarf tapeworm. but, unlike Strongyloides stercoralisThe roundworm that causes strongyloidiasis and is known as 'pinworm' in the UK and 'threadworm' in the US., H. nanaA species of murine (rat) tapeworm closely related to Hymenolepis diminuta but not suitable for use in therapy because it can reproduce within a host and spread person-to-person. Also known as Dwarf tapeworm. is exclusively an intestinal parasite that does not reach any other location. [1]

Moreover, it is possible that a therapeutic helminth infection might assist in suppressing rejection of a transplanted organ.

Quotein.gif
The results show that helminthAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths]-derived products can powerfully induce regulatory immunological mechanisms in the presence of a fully allogeneic transplant. Identification of the specific mechanisms involved in suppression of allograft rejection by helminth parasites could lead towards development of safe and effective novel therapeutic strategies. [2]
SimpleHTLogo(18x18).gif Helminthic Therapy Wiki: documenting the science, management, experience and results of helminth replacement therapy.