Helminthic therapy and neutrophils

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Home>Effects of helminthic therapy>Helminthic therapy and neutrophils

Neutrophils are normally recruited to any site of injury or inflammation, so anyone with an inflammatory condition is likely to have raised neutrophils.

After penetration of the skin by hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. larvaeThe active immature form of an insect, or an animal such as a helminth, which develops from an egg and eventually transforms again into its adult state., neutrophils are recruited, along with CD4 T cells, macrophages and eosinophilsEosinophils are a specialised type of white blood cell with a variety of both harmful and beneficial functions. Their numbers rise temporarily following inoculation with helminths., but a continuing helminth infection can cause a scarcity of neutrophils. [1]

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ParasiticAn organism that lives in or on another organism (its host) and benefits at the host’s expense. (The organisms used in helminthic therapy are, strictly speaking, not parasites, but mutualists, because they have a mutually beneficial symbiotic relationship with their hosts.) helminth infections are associated with eosinophilia; however, neutrophils are less prevalent.” [2]

One hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. host has reported that, at 23 weeks after her first inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation], her neutrophils tested below the normal range. [3]

See also

SimpleHTLogo(18x18).gif Helminthic Therapy Wiki: documenting the science, management, experience and results of helminth replacement therapy.