Helminthic therapy and inflammatory bowel disease (IBD)

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Home>Effects of helminthic therapy>Helminthic therapy and inflammatory bowel disease (IBD)

The anecdotal evidence

Several thousand people are using helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. to treat Crohn’s disease and colitis, and the following quotes demonstrate the results being achieved.

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I have been keeping Crohn's Disease and CDCrohn's disease, also known as regional enteritis, is an inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms. It primarily causes abdominal pain, diarrhea (which may be bloody if inflammation is at its worst), vomiting, or weight loss, but may also cause complications outside the gastrointestinal tract such as skin rashes, arthritis, inflammation of the eye, tiredness, and lack of concentration. arthritis in remission using only helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] for the last 10 years. HThelminthic therapy (using TTOthe ova (eggs) of the human whipworm, Trichuris trichiura, TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis and NAthe human hookworm, Necator americanus) is the best treatment I've tried and has no negative side effects. As long as I keep my colony large enough and healthy. I was diagnosed at age 12 and I'm 52 now. It has been a long struggle to find something that works. HelminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] have been a life saver for me.
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This treatment has put my UCUlcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD) which specifically affects the large intestine, or colon, causing characteristic ulcers, or open sores. The main symptom of active disease is constant diarrhea mixed with blood, of gradual onset. in complete remission and I am prescription free. I was able to get completely off prednisone, 6-MP, and asocol. I am medication free and symptom free. I feel and function completely normally! I would not have graduated, or have a career, or a normal life in any way had it not been for this therapy. I can't say enough good things about it!!!

Someone else with colitis has posted pictures of his colon before and after self-treatmentMedication or treatment of one's own disease or condition without medical assistance. with helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths].

For more pictures of this patient's colon, see:

Also see.

There are many more reports by those who are using helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] to treat Crohn’s disease and several different forms of colitis.

Research findings

Researchers at New York University were among the first to provide a link between parasitesAn organism that lives in or on another organism (its host) and benefits at the host’s expense. (The organisms used in helminthic therapy are, strictly speaking, not parasites, but mutualists, because they have a mutually beneficial symbiotic relationship with their hosts.) and the microbiomeAll the microorganisms living in and on the body, or the genome of these microorganisms. "Microbiota" refers to the specific population of microorganisms living in a certain part of the body, such as the gut. These two terms are often used interchangeably. and the origin of inflammatory bowel disease.

When researchers surveyed helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. self-treaters in 2015, they found that all four domesticated helminth species (NAthe human hookworm, Necator americanus, TTOthe ova (eggs) of the human whipworm, Trichuris trichiura, TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis and HDCHymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta) were being used to treat IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC)., with a reported efficacy rate averaging 82% for Crohn’s and 91% for colitis.

Earlier research

  • 79% of patients with Crohn’s disease who were given Trichuris suisThe porcine (pig) whipworm used in helminthic therapy and taken as microscopic eggs (TSO) in a drink every two weeks. ova (TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis) responded with a significant reduction in symptoms. [1] Weinstock and colleagues revealed that patients who had, for the most part, proven resistant to pharmaceutical treatments before being treated successfully using TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis, were literally ‘‘begging to be re-treated” after the trial was complete. [2].
  • 43.3% of patients with active ulcerative colitisUlcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD) which specifically affects the large intestine, or colon, causing characteristic ulcers, or open sores. The main symptom of active disease is constant diarrhea mixed with blood, of gradual onset. who were given TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis showed improvement, in comparison with only 16.7% of those receiving a placebo. [3] | PDF
  • An individual who self-infected with Trichuris trichiuraThe human whipworm used in helminthic therapy and taken periodically as microscopic eggs (TTO) in a drink. ova (TTOthe ova (eggs) of the human whipworm, Trichuris trichiura) experienced almost complete remission of his colitis symptoms. [4]
  • A further case of infection with TTOthe ova (eggs) of the human whipworm, Trichuris trichiura showed several indicators of mucosal and systemic immune modulation following self infection. [5]
  • Infection with Hymenolepis diminutaA murine (rat) tapeworm used in helminthic therapy that generally does not mature in humans and is taken as cysticerci (HDC) in a drink every 2 or 3 weeks. cysticercoids (HDCHymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta) was found to be superior to daily corticosteroids in the prevention of colitis in mice, and did not result in additional side effects. [6]
  • IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC). was reversed in genetically susceptible mice which were given a helminth infection, and it did this by increasing beneficial bacteria called Clostridiales which, in turn, reduced the number of disease-causing bacteria called Bacteroides. [7]
  • The risk from therapeutic helminth exposure is modest compared with the dangers of modern pharmaceutical therapies for IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC)., which are well known to promote and worsen infections with other pathogens. [8]
  • Failure to acquire helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] in early life negatively affects immune development, leading to immunological diseases such as IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC). later in life. [9]
  • Helminth exposure may prevent IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC). in children. [10] | PDF

For more research papers on helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. and IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC)., search the following page for the terms, “Crohn” or "colitis", “bowel” and “IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC).”.

Limitations of helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. in treating IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC).

Previous physical damage cannot be reversed

While the disease process can be arrested by helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy., any physical damage already done by a disease cannot be undone as a result of hosting helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths].

Duration and severity of illness, and age of patient, can restrict benefits

A favourable outcome is more likely in those who are young, have a less severe form of the disease, and have had their illness for a shorter period of time. For example, among self-treaters using NAthe human hookworm, Necator americanus who are "very sick" with IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC)., the treatment is only successful in about 40% of cases of ulcerative colitisUlcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD) which specifically affects the large intestine, or colon, causing characteristic ulcers, or open sores. The main symptom of active disease is constant diarrhea mixed with blood, of gradual onset. and 65% of Crohn’s disease patients. [11]

Intestinal fistulae and abscesses are likely to require conventional treatment

HelminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] subdue inflammation over time by gradually calming the immune response, but this effect is too subtle to deal with acute inflammation or its consequences. Therefore helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] are unlikely to be able to treat fistulae or abscesses without the additional use of medication and/or surgery. Once these conditions have been brought under control, however, the immunomodulation provided by helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] may prevent the development of further abscesses or fistulae. [12]

One helminth self-treaterSomeone who treats their own disease or condition without medical assistance. has reported that, after having a fistula surgically corrected prior to starting helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy., she was mostly in remission for the subsequent 7 years, topping up her helminth colony whenever her symptoms began to return. [13]

Helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. is compatible with conventional IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC). therapies

Helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. is fully compatible with the use of immunosuppressive drugs. See the following page section for details.

The absence of regulatory approval belies the confidence of researchers and clinicians

In spite of all the research, most gastroenterologists remain unaware of this treatment, and many of those who are aware dismiss it as unproven and potentially harmful. None are able to condone it or support its use because it has not yet been approved by any national regulatory body. However, researchers have said,

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Although self-treatmentMedication or treatment of one's own disease or condition without medical assistance. with helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] cannot be recommended by medical professionals due to a lack of blinded, placebo controlled trials, neither should it be discouraged since the available evidence suggests that it is beneficial in most cases when practiced by knowledgeable individuals. [14]

There are many doctors who are using helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. to address their own health issues (e.g., here) and those of their families (e.g., here), and scientists investigating helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. have no qualms about treating themselves with worms.

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In developed countries, where we are well nourished, worms are potentially good... If I had Crohn’s disease, ulcerative colitisUlcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD) which specifically affects the large intestine, or colon, causing characteristic ulcers, or open sores. The main symptom of active disease is constant diarrhea mixed with blood, of gradual onset. or multiple sclerosis, I would infect myself without hesitation. (Alex Loukas, Australian Institute of Tropical Health & Medicine) [15]

Selecting a suitable helminth for IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC).

Many self-treaters have found that TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis and NAthe human hookworm, Necator americanus are both very effective against Crohn’s disease, and that colitis responds well to either TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis or TTOthe ova (eggs) of the human whipworm, Trichuris trichiura. Some colitis patients have reported success using NAthe human hookworm, Necator americanus, either alone, or in combination with TTOthe ova (eggs) of the human whipworm, Trichuris trichiura, and a few have had good results treating both Crohn's and colitis with HDCHymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta. For more details about helminth selection, see the following page.

Support for IBDInflammatory bowel disease is a group of conditions affecting the gastrointestinal (GI) tract, particularly the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis (UC). patients using helminthic therapyThe reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat and prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy.

To talk with people who are using helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths] to treat Crohn's diseaseAlso known as regional enteritis, this is an inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms. It primarily causes abdominal pain, diarrhea (which may be bloody if inflammation is severe), vomiting or weight loss, but may also cause complications outside the gastrointestinal tract such as skin rashes, arthritis, inflammation of the eye, tiredness and lack of concentration. or ulcerative colitisUlcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD) which specifically affects the large intestine, or colon, causing characteristic ulcers, or open sores. The main symptom of active disease is constant diarrhea mixed with blood, of gradual onset., join the following support group.

See also

SimpleHTLogo(18x18).gif Helminthic Therapy Wiki: documenting the science, management, experience and results of helminth replacement therapy.