Self-treating with TSO

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The porcine (pig) whipwormA helminth with a tapering whiplike body that lives in the colon. In helminthic therapy, the microscopic eggs of either the human Trichuris trichiura (TTO) or pig Trichuris suis (TSO) are taken in a drink., Trichuris suisThe porcine (pig) whipworm used in helminthic therapy and taken as microscopic eggs (TSO) in a drink every two weeks., is taken in a liquid in the form of minute, barely visible eggs that are referred to as ova, hence the abbreviation, "TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis". Since this species is not adapted to living in humans, it dies approximately 14 days after ingestion, after which it is completely digested, leaving no eggs or worms to be passed in faeces. During its short time in the body, the immature worm hatches from its egg and begins to grow, shedding molecules that modulate the host’s immune system and provide a legitimate target for it to attack. This prevents the immune system from responding inappropriately to innocent targets such as foods and pollens and the host’s own tissues, as happens in autoimmune diseases such as lupus, ulcerative colitisUlcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD) which specifically affects the large intestine, or colon, causing characteristic ulcers, or open sores. The main symptom of active disease is constant diarrhea mixed with blood, of gradual onset. and Crohn’s disease.

Dosing with TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis

Available dose sizes

  • 500 ova
  • 1,000 ova
  • 2,500 ova

Recommended dosing regimen

  • For young patients with moderate symptoms - one dose of TSO500 every 14 days.
  • For adult patients with moderate symptoms - one dose of TSO1000 every 14 days.
  • For elderly patients and those with long-term illness - one dose of TSO2500 every 14 days.

Those who start with with TSO500 or TSO1000 and do not see a significant improvement in their condition by the 5th dose, should switch to the next higher dose.

The basic dosing regimen consists of a total of 10 doses, one dose being taken every 14 days. In cases of more severe or chronic disease, administration of up to 20 doses may be necessary.

Some people have found that they begin to experience a return of disease symptoms slightly before the next dose is due. In these cases, shortening the period between doses by one or two days will prevent the reappearance of symptoms.

Possible side effects and how to avoid them

Side effects are usually limited to the period immediately following the first dose and typically consist of temporary, mild gastrointestinal symptoms, especially diarrhoea.

The following adaptation regimen can be used to prevent the occurrence of diarrhoea.

  • Two doses of TSO500, followed by
  • two doses of TSO1000, and then
  • six doses of TSO2500.

If someone who starts with larger doses finds that these cause diarrhoea, they should switch to this adaptation regimen. If they do not have smaller doses to hand, these can be created by dividing the contents of a bottle that contains a larger dose. For example, to create doses of 500 from a bottle of 1000 TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis, first shake it to evenly distribute the organisms it contains, then pour out half of its contents to produce a dose of 500. After taking this dose, the 500 ova remaining in the original bottle can be stored in the fridge until required.

Occasionally, side effects may continue for several doses but will eventually reduce in severity.

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I just took my 4th dose (of 2500 TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis to treat ulcerative colitisUlcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD) which specifically affects the large intestine, or colon, causing characteristic ulcers, or open sores. The main symptom of active disease is constant diarrhea mixed with blood, of gradual onset.)… I’ve had some gas issues for the first couple days after the doses. [1] [2]
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I take them every two weeks. I do get diarrhea the day after dosing. It clears in less than 24 hours. [3]

Response to TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis

The conditions that appear to respond best to TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis are Crohn’s disease, ulcerative colitisUlcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD) which specifically affects the large intestine, or colon, causing characteristic ulcers, or open sores. The main symptom of active disease is constant diarrhea mixed with blood, of gradual onset., autism and lupus. [4]

Due to the considerable variation in how individuals respond to TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis, it is not possible to predict an accurate timeline that applies to all patients. However, it appears that around 80 percent of patients eventually respond positively to the treatment, although response and remission may take longer in the case of more severe or chronic conditions, or when individuals have been using a different helminthAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths], such as NAthe human hookworm, Necator americanus, [5] before commencing treatment with TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis.

Most people notice the first improvements between dose 4 (after 8 weeks) and dose 6 (after 12 weeks) and typically achieve remission after dose 10 (20 weeks after commencing the treatment). However, response times do vary, and more than 10 doses may be required in the case of patients with very severe or chronic disease. [6]

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I saw improvement after the 4 doses, about 8 weeks. [7]
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It took me until about the 7th dose (14 weeks) to feel better. [8]

Experience gained from the use of TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis in thousands of patients over more than a decade, both in and outside clinical studies, suggests that the earlier in the disease process that treatment is initiated, the more rapidly it will work and the longer remission is likely to last once it is achieved.

If patients stop treatment after remission is achieved, they don’t usually relapse again for between 1 and 3 years and, if they do flare again, resuming dosing with TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis will usually result in a return to remission. It is recommended that those who do flare again should take a periodic maintenance dose, for example 1 dose of TSO500 every 6 or 8 weeks.

One of the benefits of using a short-lived non-human helminth such as TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis or HDCthe cysticercoids (larval cysts) of the rat tapeworm, Hymenolepis diminuta is that, in comparison with the human-adapted helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths], NAthe human hookworm, Necator americanus and TTOthe ova (eggs) of the human whipworm, Trichuris trichiura, it is easier to experiment with the size and frequency of doses to find the optimal regimen for each individual.

Where do TSthe porcine (pig) whipworm, Trichuris suis live?

In humans, TSthe porcine (pig) whipworm, Trichuris suis have been observed to settle predominantly in the caecum and the ascending and transverse sections of the colon, [9] as shown by the red text in the following representation.


mouth ➤ oesophagus ➤ stomach ➤ duodenumjejunumileumcaecumAscending colonTransverse colonDescending colon ➤ rectum

The question of possible TSthe porcine (pig) whipworm, Trichuris suis persistence

There is very little evidence to suggest that TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis might develop to adulthood and persist in humans, and some of the evidence that has appeared lacks credibility.

The first two reports, above, both concerned single individuals. In the first, patent infection was claimed on the basis of a biopsy and, in the second, by colonoscopy and the passage of unembryonated whipwormA helminth with a tapering whiplike body that lives in the colon. In helminthic therapy, the microscopic eggs of either the human Trichuris trichiura (TTO) or pig Trichuris suis (TSO) are taken in a drink. eggs in the subject’s faeces.

The subject in the second study had previously hosted the human whipwormA helminth with a tapering whiplike body that lives in the colon. In helminthic therapy, the microscopic eggs of either the human Trichuris trichiura (TTO) or pig Trichuris suis (TSO) are taken in a drink., Trichuris trichiuraThe human whipworm used in helminthic therapy and taken periodically as microscopic eggs (TTO) in a drink. (TTthe human whipworm, Trichuris trichiura), which was assumed by those conducting the study to have been eradicated following the administration of mebendazole. However, the use of mebendazole to eradicate TTthe human whipworm, Trichuris trichiura is not reliable (see Terminating a human whipworm infection) so, in spite of the bold claim by the researchers that they were the first to report a patent TSthe porcine (pig) whipworm, Trichuris suis infection in a human volunteer undergoing TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis treatment, it is likely that the adult whipwormsA helminth with a tapering whiplike body that lives in the colon. In helminthic therapy, the microscopic eggs of either the human Trichuris trichiura (TTO) or pig Trichuris suis (TSO) are taken in a drink. observed in this case were TTthe human whipworm, Trichuris trichiura and not TSthe porcine (pig) whipworm, Trichuris suis. And, as for the unembryonated eggs observed in this subject’s faeces, these may have been from a dose of TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis, which would inevitably contain at least 3% unembryonated eggs since the TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis production method has a maximum embryonation rate of 97%. [10] Also see the additional comments about this case study in this discussion thread.

In the third study, above, only a single sample of Trichuris eggs showed a similarity to sequences of TSthe porcine (pig) whipworm, Trichuris suis.

Overall, the number of reports of TSthe porcine (pig) whipworm, Trichuris suis persistence in humans is minuscule and no adult stage of TSthe porcine (pig) whipworm, Trichuris suis has been observed in any of the clinical trials that have used this species, even though they have included hundreds of patients. To read these studies, search the following page for "Trichuris suisThe porcine (pig) whipworm used in helminthic therapy and taken as microscopic eggs (TSO) in a drink every two weeks.".

It has been reported anecdotally by one researcher that individual TSthe porcine (pig) whipworm, Trichuris suis can survive for as long as 6 weeks but, in the few cases where this has been observed, no adverse effects were reported.

Manufacturer and supplier of TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis

The strain of TSOthe ova (eggs) of the porcine (pig) whipworm, Trichuris suis supplied by Tanawisa was originally sourced from the United States Department of Agriculture farms in Baltimore, Maryland, and was used in the studies by Weinstock et al, and in all other clinical trials in humans. [11]

Further reading

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