Helminthic therapy and fibromyalgia

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Improvement in fibromyalgia is unlikely, but has been seen in a few cases

In the vast majority of cases, It is unlikely that helminthic therapyThe reintroduction of a controlled number of carefully selected benign intestinal worms in the form of larvae or eggs to reconstitute a depleted microbiome in order to treat or prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. will help Fibromyalgia.

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I have hosted hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. for over 2 years, and whipwormA helminth with a tapering whiplike body that lives in the colon. In helminthic therapy, the microscopic eggs of either the human Trichuris trichiura (TTO) or pig Trichuris suis (TSO) are taken in a drink. … for about 10 months... The fibro pain is unchanged. [1]

Eighteen months later, this individual had still had no relief for her fibromyalgia, in spite of continuing to host hookwormsA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin..

However, a few people with fibromyalgia have seen a small improvement after introducing helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths].

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It's almost been a year on HWhookworm, usually referring to the human hookworm, Necator americanus and I have about 30. I use small doses because of fibromyalgia. Also I seem to have less fibro attacks. [2]

Those with fibromyalgia can treat coexisting conditions if very careful

While fibromyalgia is unlikely to respond in most cases, it is possible for those with this condition to use helminthic therapyThe reintroduction of a controlled number of carefully selected benign intestinal worms in the form of larvae or eggs to reconstitute a depleted microbiome in order to treat or prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. to treat coexisting conditions.

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I have both fibromyalgia and CFS/ME and was first inoculated just over 2 years ago. I have found improvement, especially since it has helped with inflammation. It is not a cure for me but I have been able to slowly go off medications, get less infections, have less flare days, and recover quicker than I use to. [3]

Because fibromyalgia patients are typically extremely sensitive to helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths], these need to be introduced very gradually and in very small numbers. For example, no more than 5 hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. larvaeThe active immature form of an insect, or an animal such as a helminth, which develops from an egg and eventually transforms again into its adult state. should be used for the initial inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation], and 3 may be a better starting dose. This may appear to be over-cautious, but it really is the only way for someone with fibromyalgia to begin helminthic therapyThe reintroduction of a controlled number of carefully selected benign intestinal worms in the form of larvae or eggs to reconstitute a depleted microbiome in order to treat or prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. without triggering severe side effects.

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I started with 25 (hookwormsA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin.) and had an awful time, killed (them) and took 7 instead. I only redose 7 at a time. [4]
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I had 10 HWhookworm, usually referring to the human hookworm, Necator americanus to start and thought I was going to die. But I could do 3. And then another 3. And then I could stand 5.
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I have both ME and Fibro and 5 HWs was perfect for my first dose. [5]

Even starting with five hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. larvaeThe active immature form of an insect, or an animal such as a helminth, which develops from an egg and eventually transforms again into its adult state. can cause challenging side effects in some people with fibromyalgia.

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I started with a five hwhookworm, usually referring to the human hookworm, Necator americanus dose four days ago. But joint pain and muscle fatigue started to kick in yesterday and then today with a vengeance. I'm so glad now it was just five I started with. [6]
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After my first dose of 5HW I experienced extreme fatigue. It wasn't until my third dose that things began to make a big shift. [7]

While people who do not have fibromyalgia are able to avoid or reduce helminth side effects by taking prednisone, the drug may not have this effect in someone with fibromyalgia.

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I had a terrible time with inoculating 10 (after a successful run with 5) and prednisone did not relieve my fibromyalgia/ME flare in any way (20mg/day). [8]

Once a total of about 10 hookwormsA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. has been inoculated, and these have been established for six months, higher doses may be tolerated, but caution is still required to prevent triggering side effects.

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I started out with 5HWs because I have Fibromyalgia. I am using HThelminthic therapy to treat allergies, arthritis, IBSIrritable bowel syndrome is a widespread condition involving recurrent abdominal pain and diarrhoea or constipation. [https://en.wikipedia.org/wiki/Irritable_Bowel_Syndrome Wikipedia:Irritable_Bowel_Syndrome], leaky gut, psoriasis, etc… For me the 5HWs was very gentle… My second dose was 10HWs and it was a little more noticeable causing very mild flare. My last 2 doses were 25HWs and there is a huge difference… my eczema and psoriasis pops up and drives me crazy with addition itching. Arthritis also seems to reappear, and lot of diarrhea and abdominal cramping. [9]
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For me 5HWs is a dose where I obtain the most benefit with the fewest side effects. [10]

The size of both doses and total colony may remain limited indefinitely

Some people may never be able to tolerate more than 15 or 20 hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. larvaeThe active immature form of an insect, or an animal such as a helminth, which develops from an egg and eventually transforms again into its adult state. at any one time, and there may be a similar limit on the dose size of other helminth species. For example, someone with fibromyalgia who began using HDCthe cysticercoids (larval cysts) of the rat tapeworm, Hymenolepis diminuta to treat another condition has reported that she was able to take 10 HDCthe cysticercoids (larval cysts) of the rat tapeworm, Hymenolepis diminuta every 4 weeks for five months without worsening any of her existing symptoms. [11] (When HDCthe cysticercoids (larval cysts) of the rat tapeworm, Hymenolepis diminuta is being used to treat, rather than prevent a condition, the doses used typically range between 30 and 60, taken every 2 weeks.)

Even when they have a well established hookwormA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. colony, fibromyalgia patients may find that they have an individual colony size limit that cannot be exceeded.

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My dosing schedule was: 5 + 5 + 25 + 25 + 25 etc… With this schedule I had no side effects whatsoever. I think my optimal total is about 70 worms or so. Unfortunately I did not know this at the time and I went on adding too may worms which resulted in getting very sick again. I just killed my worms and will start again from scratch, aiming for (a maximum colony size of) 70. [12]

Other conditions that may respond in a similar way to fibromyalgia

The need to start with very small doses, to increase these very gradually and, in the case of the human helminthsAn intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. [https://en.wikipedia.org/wiki/Helminths Wikipedia:Helminths], NAthe human hookworm, Necator americanus and TTthe human whipworm, Trichuris trichiura, to limit the total colony size, also applies to several other conditions, which include:

  • Chronic Fatigue Syndrome (CFS/M.E.)
  • Multiple Chemical Sensitivity (MCSMultiple Chemical Sensitivity is a chronic physical illness affecting people of all ages and backgrounds. It involves allergic-type reactions to very low levels of chemicals in everyday products and often also sensitivity to food, medicines, moulds and electromagnetic fields. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241652/ A review of a two-phase population study of multiple chemical sensitivities])
  • multiple food intolerance
  • narcolepsy
  • eosinophilic esophagitis
  • eosinophilic gastroenteritis
  • mast cell disorders
  • mitochondrial dysfunction
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    CFS/M.E. sufferer here. I took 5 NAthe human hookworm, Necator americanus in Sep 2015, with few side effects. Waited 5 months and re-dosed with 10 NAthe human hookworm, Necator americanus in early Feb. Am experiencing the worst flare in 5 years, since day 12 post inoculationThe introduction of an infectious agent into an organism. [http://helminthictherapywiki.org/wiki/index.php/Helminth_inoculation Helminth inoculation] (now day 22). [13]

Very cautious dosing is even more important for females because they appear to fare somewhat worse than males.

There is much more detail about dosing with hookwormsA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin. on the Hookworm dosing and response page.

Treating side effects

Prednisone is sometimes taken during the early stages of helminthic therapyThe reintroduction of a controlled number of carefully selected benign intestinal worms in the form of larvae or eggs to reconstitute a depleted microbiome in order to treat or prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. to reduce the side effects - which it does very effectively - but this drug should only be taken under the supervision of a doctor.

Allergy medication can also help.

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I suffer with Fibromyalgia and CFS/ME (other things as well) and had a terrible flare with an increased dose. Allergy medication helped me more than anything else because it calmed down my reaction. [14]

For more on treating the initial side effects of helminthic therapyThe reintroduction of a controlled number of carefully selected benign intestinal worms in the form of larvae or eggs to reconstitute a depleted microbiome in order to treat or prevent chronic inflammation, autoimmune disease and other immunological disorders including allergy. using hookwormsA helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin., see this page section:

SimpleHTLogo(18x18).gif Helminthic Therapy Wiki: documenting the science, management, experience and results of helminth replacement therapy.